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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Use of public water supply fluoride concentration as an indicator of population exposure to fluoride in England 1995–2015.

July 14, 2020 | Environmental Monitoring and Assessment | Roberts DJ, Morris J, Wood A, Verlander NQ, Leonardi GS, Fletcher T. | 192:514.
Abstract Public health monitoring of Community Water Fluoridation (CWF) schemes requires estimates of exposure to fluoride in public water supplies (PWS). We aimed to use routine data to estimate population exposure to PWS-fluoride in England and to determine whether PWS-fluoride exposure from 2005 to 2015 could be used as a proxy for exposure for 1995–2004, when fluoride concentration data that could be linked to population health data were unavailable. We calculated annual mean water

Slightly Elevated Serum Ionic Fluoride Levels Inhibit Insulin Secretion and Increase Glucose Levels in a General Japanese Population: a Cross-sectional Study.

October 8, 2020. | Biological Trace Element Research | Itai K, Onoda T, Nohara M, Kuribayashi T, Tanno K, Ohsawa M, Mori M, Okayama A. | [Epub ahead of print]
References 1.  Whitford GM (1996) The metabolism and toxicity of fluoride. Monogr Oral Sci 16. Rev 2. 1–153 2.  Tsunoda N, Sakurai S, Tsunoda H (1986) Gastrointestinal absorption of fluoride in humans—a comparative study of NaF and CaF2. In: Humio T and Ming-Ho Yu (ed) Fluoride research 1985, studies in environmental science 27. Elsevier, Amsterdam, pp389–394 3.  Everett ET (2011) Fluoride's effects on the formation of teeth and bones, and the influence of genetics. J D

Effects of Fluoride Long-Term Exposure over the Cerebellum: Global Proteomic Profile, Oxidative Biochemistry, Cell Density, and Motor Behavior Evaluation.

October 2, 2020 | International Journal of Molecular Sciences | Lopes GO, Ferreira MKM, Davis L, Bittencourt LO, Aragao WAB, Dionizio A, Buzalaf MAR, Crespo-Lopez ME, Maia CSF, Lima RR. | 21(19):7297.
Funding This study was financed by the National Council for Scientific and Technological Development (CNPq) from Brazilian Ministry of Science, Technology, Innovation and Communications (MCTI) process number: 435093/2018-5 approved by R.L. L.B. and A.D. received CNPq and FAPESP scholarships, respectively. M.B., M.E.C.-L. and C.M. thanks for CNPq fellowship. The APC was funded by Pró-Reitoria de Pesquisa e Pós-graduação da Universidade Federal do Pará (PROPESP-UFPA). Acknowledg

The effect of vitamin E and selenium combination in repairing fluoride-induced DNA damage to NRK-52E cells.

October 6, 2020 | Molecular Biology Reports | Yuksek V, Cetin S, Usta A. | [Epub ahead of print]
References Anuradha CD, Kanno S, Hirano S (2001) Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells. Free Radical Biol Med 1:367–373 Article  Google Scholar Bai C, Chen T, Cui Y, Gong T, Peng X, Cui HM (2010) Effect of high fluorine on the cell cycle and apoptosis of renal cells in chickens. Biol Trace Elem Res 138:173–80 CAS  PubMed  Article  Google Scholar Barbier O, Arreola-Mendoz

Comparison of oral health indicators between two places of endemic dental fluorosis in Jordan.

April 18, 2020 | The Saudi Dental Journal | Al-Omoush SA, Al-Tarawneh S, Abu-Awwad M, Sartawi S, Elmanaseerm W, Alsoleihat F. | [Epub ahead of print]
Introduction Excessive fluoride intake during tooth development causes dental fluorosis. Aim This study aimed to (1) determine the prevalence of dental fluorosis in association with fluoride concentrations in drinking water, (2) explore the effects of altitude on the severity of fluorosis in two towns with high fluoride levels in the drinking water, and (3) assess decayed, missing, and filled teeth (DMFT) and oral hygiene practices among participants. Material and methods

Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain-pituitary-gonadal axis in male rats.

June 27, 2017 | Canadian Journal of Physiology and Pharmacology | Adedara IA, Olabiyi BF, Ojuade TD, Idris UF, Onibiyo EM, Farombi EO. | 95(9):1019-1029.
References   Abd El Tawab AM, Shahin NN, AbdelMohsen MM. 2014. Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats. Chem.-Biol. Interact. 224: 196-205 Crossref, Medline, ISI, Google Scholar.   Adedara IA, Ojuade TJD, Olabiyi BF, Idris UF, Onibiyo EM, Ajeigbe OF, Farombi EO. 2017. Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride. Biol. Trace Elem. Res. 175: 388-395 Crossref, Medl

Investigation of the genotoxic effects of fluoride on a bone tissue model .

October 1, 2020 | Toxicological Research | Volobaev VP, Kalyuzhnaya EE, Schetnikova EA, Korotkova AD, Naik AA, Bach SN, Prosekov AY, Larionov AV. | 36:337–342.
References Lav KH, Baylink DJ (1998) Molecular mechanism of action of fluoride on bone cells. J Bone Miner Res 13:1660–1667 Article  Google Scholar Perumal E, Paul V, Govindarajan V, Panneerselvam L (2013) A brief review on experimental fluorosis. Toxicol Lett 223:236–251 CAS  Article  Google Scholar Purohit SD, Gupta RC, Mathur AK, Gupta N, Jeswani ID, Choudhary VK (1999) Experimental pulmonary fluorosis. Indian J Chest Dis Allied Sci 41:27–34 CAS  Pu