Fluoride Action Network


Effects of fluoride (F) on electrocardiogram (ECG) values were determined in ten healthy adult male New Zealand white rabbits. After the initial ECG values were measured, the rabbits were administered 20 mg NaF/kg body weight by oral intubation for two months, and the new ECG values were determined. There was a significant (p<0.001) decrease in the R-R interval (duration between the peaks of two consecutive R waves of ECG) and P-R interval (duration from the starting of P wave to the starting of QRS complex in ECG), while significant (p<0.001) increases in the mean heart rate and corrected QT intervals were observed compared to the initial baseline values. The results indicate that F adversely affects the ECG in male rabbits.