The fluoride sensitivity of cells released from rat livers and kidneys by collagenase perfusion was investigated by measuring effect on protein synthesis rate in vitro. Both cell types were sensitive to fluoride with clear concentration/effect relationships. Significant difference in sensitivity for fluoride between the cell types was found, with the kidney cells being the most sensitive type.
Effect of sodium fluoride on the expression of Bcl-2 family and osteopontin in rat renal tubular cells
Our earlier studies showed that the apoptosis of renal tubules can be induced by sodium fluoride (NaF). The present study was designed to estimated the effects of B-cell lymphoma/leukemia 2 (Bcl-2), Bcl-2-associated protein X (Bax), and osteopontin (OPN) on the apoptosis of renal tubular cells induced by NaF at different
[Fluoride osteosis of hydro-telluric origin in a female patient with renal insufficiency. Apropos of a case with histomorphometric analysis].
We report a case of fluorosis due to high water and soil contents in a 23-year-old Algerian woman. The condition, which is infrequent at this age, was promoted by chronic renal failure due to a congenital renal malformation. Roentgenograms showing osteosis with increased bone density were suggestive of fluorosis rather
Epidemiologic health study of workers in an aluminum smelter in Kitimat, B.C. II. Effects on musculoskeletal and other systems
A health study was carried out on 2066 workers in an aluminum smelter in Kitimat, British Columbia to study the effects of exposure to fluoride and other air contaminants encountered on the potlines on the musculoskeletal system, hemopoietic tissue, liver, and renal function. Three hundred seventy-two railway repair workers from
The effect of fluoride on enamel and dentin formation in the uremic rat incisor
Renal impairment in children is associated with tooth defects that include enamel pitting and hypoplasia. However, the specific effects of uremia on tooth formation are not known. In this study, we used rat mandibular incisors, which continuously erupt and contain all stages of tooth formation, to characterize the effects of
Effect of sodium fluoride administration on body changes in old rats
The effects of feeding low levels of sodium fluoride from conception until old age were determined in a total of 456 albino rats. Four levels of sodium fluoride (0, 1, 5, and 10 PPM fluorine) were given to 4 groups of animals in their drinking water. In one study half
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