Abstract

Endemic fluorosis is a systematic disease. We investigated the serum free fluoride, thyroid hormones and TSH concentrations in 37 cases. Significantly lowered serum T4 and T3 and increased TSH were found in patients. Patients’ serum rT3 concentrations were not significantly different from the controls. Significant negative correlations were found between serum free fluoride concentrations and T3 concentrations or T3/T4 ratios. We proposed that fluoride intoxication might decrease the thyroid function and suggested the method of prevention and treatment of this condition.

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  • Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats: a multigenerational assessment.

    High-fluoride (100 and 200 ppm) water was administered to rats orally to study the fluoride-induced changes on the thyroid hormone status, the histopathology of discrete brain regions, the acetylcholine esterase activity, and the learning and memory abilities in multigeneration rats. Significant decrease in the serum-free thyroxine (FT4) and free triiodothyronine (FT3)

  • Effects of high fluoride and low iodine on thyroid function in offspring rats

    Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water (45 mg F- L-1 from 100 mg NaF L-1), low dietary iodine (0.0855 mg kg-1), or both together in order to

  • Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride- affected hilly areas of Doda District, Jammu and Kashmir, India.

    A case-control study was undertaken among the school children aged 8-15 years to know the presence and severity of dental fluorosis, nutrition and kidney status, and thyroid function along with bone metabolic indicators in Doda district situated at high altitude where drinking water was contaminated and heat stress. This study

  • A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas.

    Abstract The study was undertaken to determine serum/urinary fluoride status and comparison of free T4, free T3 and thyroid stimulating hormone levels of 8 to 15 years old children with and without dental fluorosis living in an endemic and non-endemic fluorosis area. A sample group of 60 male and female school children,

  • Measurement of the content of T3, T4, and TSH in children in endemic fluorosis areas

    The contents of T3, T4, TSH, urine fluoride, and urine iodine in 8-12 year-old children [were measured] in endemic fluorosis areas (water fluoride 3.52 mg/L). The results are: T4 content significantly decreased in the blood. T3 and TSH content was significantly elevated, and there is a positive correlation between the

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  • Fluoride's Impact on Thyroid Hormones

    Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as

  • Fluoride & Goiter

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