Inorganic fluoride in whole blood, serum, or plasma has been determined with a fluoride ion-selective electrode by adding the 0.5- to 2.0-mL sample to 20 mL of water containing a buffer and fluoride, 25 micrograms/L. The fluoride concentration in the sample is calculated from the resulting cell potential difference recorded after equilibrating for 10 min. This novel method has the advantages of simplicity, accuracy, and high precision, standard deviations for 5 to 7 replicate determinations of fluoride ranging from +/- 1.7 to +/- 2.4 micrograms/L. For whole blood from donors living in an area with fluorinated drinking water, the F- concentration was 20 to 60 micrograms/L.
Health risk assessment of fluorine in fertilizers from a fluorine contaminated region based on the oral bioaccessibility determined by Biomimetic Whole Digestion-Plasma in-vitro Method (BWDPM).
Highlights Determine F bioaccessibility by Biomimetic Whole Digestion-Plasma in-vitro Method. More bioaccessible F was determined in small intestine and plasma. High occupational exposure risk of F to local farmers should be concerned. Same factor may not be equal in effects on F bioaccessibility and exposure risk. Due to potential adverse
[Osteoporosis therapy and thyroid function. Influence of 6 months of sodium fluoride treatment on thyroid function and bone density]
26 women were treated for osteoporosis with 40 mg of sodium fluoride twice a day (equivalent 36 mg of fluorine) for a longer period. Mostly by reason of incompatibility, a reduction to half of the dose was necessary in six of these patients. The control of plasma fluoride concentration indicated
Fluoride level in plasma blood and urine of first-trimester pregnant women living in a province.
The study was aimed to determine the fluoride level in blood and urine of 154 first-trimester pregnant women among 7 public hospitals of a province. The concentration of plasma-blood fluoride was not determined in all subjects. For concentration of urine fluoride concentration, 77 cases (50.6%) had low fluoride level (less
Associations of fluoride exposure with sex steroid hormones among U.S. children and adolescents, NHANES 2013–2016.
Highlights Plasma fluoride is related to lower testosterone and estradiol in male adolescents. Water fluoride is inversely associated with SHBG in male adolescents. Plasma fluoride is inversely associated with SHBG in female children. Fluoride mediated disruption of sex steroid hormones has been demonstrated in animals. However, evidence from humans was limited
Serum fluoride levels following commencement of methoxyflurane for patient analgesia in an ambulance service.
Editor—Methoxyflurane, once a frequently used anaesthetic agent,1 is re-emerging as an inhalation analgesic. In modern practice, it is given in doses of up to 6 mL via a proprietary patient-controlled self-delivery device2 with an activated carbon filter designed to adsorb some methoxyflurane vapour from the patient's exhaled breath.3 Methoxyflurane is an
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