Abstract

Our previous study reported the lethal dose of cadmium fluoride (CdF₂, CdF for short) 24 hours after intravenous injection in rats, the dose-effect relationships and the metabolism of cadmium (Cd) and fluoride (F) in bile and urine for investigating the acute toxicities from the standpoint of occupational health. This study was designed to determine the early dynamics of the absorption, systemic distribution, and metabolism of CdF. The kinetics of Cd and F were investigated in the blood in rats as a model of accidental occupational exposure to CdF. Rats were received a single intravenous injection of saline or CdF (1.34, 2.67, or 4.01(LD₈₈)mg/kg) which were the same doses of the previous study. Because this study investigates the dose-effect relationships of serum kinetic changes of Cd and F. Blood samples were obtained from each individual animal 0, 5, 10, 30, 60, 120, and 300 min after the CdF administration. The serum concentration-time profiles were analyzed by compartmental modeling using the WinNonlin program. These kinetic profiles indicated that the clearance of Cd was diminished in the 2.67 and 4.01 mg/kg groups. The abnormal kinetics of Cd was attributable to caused by severe hepatic injury that diminished the capacity for Cd accumulation. The elimination of serum F was delayed in the 4.01 mg/kg group. The abnormal kinetics of F was attributable to caused by nephrotoxicity that diminished its elimination from the kidney.

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