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Efficacy and Safety of Postmenopausal Osteoporosis Treatments: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
References Cheng, L.; Zhang, K.; Zhang, Z. Effectiveness of thiazides on serum and urinary calcium levels and bone mineral density in patients with osteoporosis: A systematic review and meta-analysis. Drug Des. Dev. Ther. 2018, 12, 3929–3935. [Google Scholar] [CrossRef] Cummings, S.R.; Melton, L.J. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002, 359, 1761–1767. [Google Scholar] […]
Fluoride exposure may accelerate the osteoporotic change in postmenopausal women: animal model of fluoride-induced osteoporosis
Sodium fluoride in the treatment of osteoporosis and other bone diseases.
In a study of workers exposed to cryolite (sodium aluminum fluoride) dust for many years, Roholm (1) found that some had severe chronic skeletal fluorosis but that in a greater number there was radiologic evidence of osteosclerosis which was not associated with symptoms. This observation led Rich and Ensinck (2) to administer sodium fluoride to […]
Periostitis deformans due to wine fluorosis.
Fluoric Arthropathies: Around joints, thick marginal osteophytes develop. In some instances, they grow to such an extent as to block joint movement (‘blocking arthrosis’). The joint block can also be induced by calcification of the periarticular ligament. The most common sites of articular involvement are the hips, the sacroiliac, elbow and knee joints. In older […]
Fluoride & Spontaneous Hip Fractures in Osteoporosis Patients
Due to its ability to increase vertebral bone mass, fluoride has been used as an experimental treatment for osteoporosis (doses > 20 mg/day). Fluoride treatment, however, proved far more harmful than beneficial. Not only was fluoride therapy shown to increase fracture rates among the treated patients, it was also found to cause spontaneous hip fracture. The […]
Clinical Trials: Fluoride Treatment & Bone Fracture in Osteoporosis Patients
Due to its ability to increase bone mass, fluoride has been used as an experimental treatment for osteoporosis. The results, however, have generally been disastrous. Rather than prevent bone fractures in osteoporosis patients, fluoride therapy (at doses of 20-34 mg/day) was repeatedly found to increase fracture rates. One of the most common sites for fluoride-induced fracture […]