Many modern pharmaceuticals (e.g. Prozac, Paxil) contain “organofluorines.” An organofluorine is a chemical compound that contains both carbon and fluorine. The fact, however, that a pharmaceutical is made with an organofluorine does not mean that it will increase your exposure to fluoride. This is because the fluorine in the drug forms a very strong bond with the carbon and this bond resists metabolizing into fluoride ion. It is generally believed, therefore, that most organofluorine drugs do not contribute to daily fluoride exposure.
There are some organofluorine drugs, however, that do metabolize into fluoride. This is evident by studies finding elevated levels of fluoride showing up in the urine or blood following use of the drug. Because organofluorine drugs contain high quantities of fluorine, any drug that metabolizes into fluoride will likely be a very large source of daily exposure. Drugs that are known to break down into fluoride ion include: fluorinated anesthetics, Cipro, Niflumic acid, Flecainide, and Voriconazole. It is possible, and indeed likely, that other drugs do so as well, but have not yet been discovered.
The following are a list of studies documenting inorganic fluoride exposure from the use of organofluorine drugs:
Anesthetics (Isoflurane, Sevoflurane)
Hoemberg M, et al. (2012). Plasma fluoride concentrations during prolonged administration of isoflurane to a pediatric patient requiring renal replacement therapy. Paediatric Anaesthia 22(4):412-3.
Oc B, et al. (2012). The effects of sevoflurane anesthesia and cardiopulmonary bypass on renal function in cyanotic and acyanotic children undergoing cardiac surgery. Renal Failure 34(2):135-41.
Pradhan KM, et al. (1995). Safety of ciprofloxacin therapy in children: magnetic resonance images, body fluid levels of fluoride and linear growth. Acta Paediatrica 84(5):555-60.
Rimoli CN, et al. (1991). Relationship between serum concentrations of flecainide and fluoride in humans. Boll. Chim. Farmaceutico 130(7):279-82.
Gras-Champel V, et al. (2003). [Chronic fluorine intoxication during prolonged treatment with niflumic acid]. [Article in French] Presse Med. 2003 Jun 7;32(20):933.
Welsch M, et al. (1990). [Iatrogenic fluorosis. 2 cases]. [Article in French] Therapie. 45(5):419-22.
Meunier PJ, et al. (1980). Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis? Clin Orthop Relat Res. 148:304-9.
Prost A, et al. (1978). [Fluorine osteosis caused by a very long-term niflumic acid treatment in 2 cases of rheumatoid arthritis]. [Article in French] Rev Rhum Mal Osteoartic. 45(12):707-16.
Wermers RA, et al. (2011). Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy. Clinical Infectious Diseases 52(5):604-11.
Chen L, Milligan ME. (2011). Medication-induced periostitis in lung transplant patients: periostitis deformans revisited. Skeletal Radiology 40:143-48.
No Link Found Between (Low-Fluoride) Bottled Water and Tooth Decay
Over the past decade, there has been a steady drumbeat of press warning of the risks from drinking bottled water. The idea -- kept alive by press releases from dental associations -- is that because most bottled waters have low levels of fluoride, people switching from tap water (which is usually fluoridated) to bottled
Some Young Children Get Too Much Fluoride
THE FLUORIDATION of public water systems in the U.S. since 1945 is often hailed as one of the great public-health advances of the century. Today, many children reach adulthood without a single cavity. But now health researchers are questioning whether Americans, particularly children, may have too much fluoride in their diets. The
Are we getting too much fluoride?
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Exposure Pathways Linked to Skeletal Fluorosis
Excessive fluoride exposure from any source -- and from all sources combined -- can cause skeletal fluorosis. Some exposure pathways , however, have been specifically identified as placing individuals at risk of skeletal fluorosis. These exposure pathways include: Fluoridated Water for Kidney Patients Excessive Tea Consumption High-Fluoride Well Water Industrial Fluoride Exposure Fluorinated Pharmaceuticals (Voriconazole
Hydogen Fluoride - EPA 2000
HYDROFLUORIC ACID(a) 7664-39-3 Hazard Summary-Created in April 1992; Revised in January 2000 Hydrogen fluoride is used in the production of aluminum and chlorofluorocarbons, and in the glass etching and chemical industries. Acute (short-term) inhalation exposure to gaseous hydrogen fluoride can cause severe respiratory damage in humans, including severe irritation and pulmonary edema. Severe
Fluoride Content of Various Processed Beverages
When fluoride is added to public water supplies, it does not just go into the water, it goes all into all of the food products made with that water (e.g., soda, juice, beer, cereal, soup, etc). As a result, people living in non-fluoridated communities of heavily fluoridated countries like the
Naturally Occurring Levels of Fluoride in Fresh Food
Over the past 100 years, the levels of fluoride in foods purchased at the grocery store have increased. The reasons for this increase include: (1) the mass fluoridation of water supplies in some countries, (2) the introduction of fluoride-based pesticides, (3) the use of mechanical deboning processes, and, perhaps, (4)
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