Abstract

As fluoride inhibits Glycolysis we conducted a preliminary study to analyse the effect of fluoride on blood glucose in the individuals of endemic fluorosis area .

The study was conducted to correlate the serum fluoride with blood glucose levels in a population living in endemic fluorosis area

The present study included serum samples of 104 male and female of various age groups 20 – 70 yrs. The patients had attended OPD of Kamineni Institute of medical sciences hospital and advised for RBS. Blood glucose was estimated by hexokinase method using Dade Behring Dimension AR. Serum fluoride was estimated using ion selective electrode ECOSAN statistical analysis was done by using SPSS software.

Based on our findings, we made 3 different groups .Group-I comprised of both having increased RBS and fluoride levels(Males 4%, Females 5%) Group II comprised of patients having increased serum fluoride levels with normo glycemia (Males 44% Females 44%) and Group III consisted of patients having hyper glycemia and normal fluoride ( Males 8% Females 1%).Results obtained were compared between groups I,II,III.

There was no significant correlation between serum fluoride and hyper glycemia in endemic fluorosis area. This could be due to less sample number. None the less we are still continuing with the study.

• Related Studies :

  • Fluoride-induced resistance to insulin in the rat.

    The insulinic response of rats challenged with glucose at different times after an oral dose of 40 µmol NaF/100 g bw revealed the concentration of the molecular species reacting with anti-insulin antibody was significantly lower after 3 hr, and the glucose levels were somewhat higher than in controls. At the

  • Effect of sodium fluoride on bone biomechanical and histomorphometric parameters and on insulin signaling and insulin sensitivity in ovariectomized rats

    Osteoporosis is a systemic disease characterized by bone degradation and decreased bone mass that promotes increased bone fragility and eventual fracture risk. Studies have investigated the use of sodium fluoride (NaF) for the treatment of osteoporosis. However, fluoride can alter glucose homeostasis. The aim of this study was to evaluate

  • Bone mass increase and glucose tolerance in rats chronically treated with sodium fluoride.

    Female rats were treated with fluoride for 100 days (between 21 and 121 days of age) replacing the water supply with a 5 mM NaF solution. Bone mass was assessed by destructive physical and chemical measurements on the whole skeleton, that gave an overall view not reported previously. Bone mass

  • [Changes in bone mass and in glucose homeostasis in subjects with high spontaneous fluoride intake]

    This paper reports metabolic data of 24 women and two men, 44-66 years old, ex-residents in an area of endemic fluorosis close to Bahía Blanca city. Fasting fluoremias of these subjects (0.5 to 9.2 microM) and daily urinary fluoride excretion (> 60 mumoles/day) are characteristics of zones with endemic fluorosis.

  • Antihyperglycemic and antihyperlipemic effects of Mangifera Indica L. in fluoride induced toxicity.

    A chronic intake of fluoride through food and drinking water is also known to cause hyperglycemia and dyslipidemia besides fluorosis. The present study deals with the effects of fluoride (100 ppm) induced hyperglycemia and dyslipidemia and the alleviatory potential of Mangifera indica L. on the carbohydrate and lipid profiles in

• Related FAN Content :

  • Fluoride & Insulin

    Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics

  • Fluoride & Impaired Glucose Tolerance

    The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs

  • NRC (2006): Fluoride's Effect on Glucose Metabolism

     This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific

  • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus

    This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In

  • Fluoride Sensitivity Among Diabetics

     This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions