Abstract

In experiments with 76 rats it was demonstrated that withdrawal of fluoride from fluoride-intoxicated rats caused an improvement in the interstitial inflammation and a marked reduction of the dilated convoluted tubules and Henle loops of the kidney.

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    Highlights Fluoride exposure increased renal injury biomarkers (ALB, Cys-C, KIM-1 and OPN). Fluoride could be considered an environmental kidney toxicant. Exposure to low concentrations of arsenic does not increase kidney injury biomarkers. Co-exposure to low arsenic level does not enhanced renal fluoride toxicity. Fluoride (F) is a toxicant widely distributed

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  • Topical fluorides: effects on physiologic and biochemical processes

    The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in

  • Effects of chronic fluoride intake on the antioxidant systems of the liver and kidney in rats

    Excessive fluoride intake over a long period of time can lead to fluorosis, which may cause dental and skeletal manifestations. Metabolic, functional and structural damage caused by chronic fluorosis have been reported in many tissues, but the exact mechanisms modulated by fluoride remain unclear. The aim of this study was

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