Abstract
SUMMARY: Wistar rats were given 20 ppm fluoride in drinking water, or single administration of 115 mg/kg alloxan i.m. to induce diabetes, or single administration of 115 mg/kg alloxan i.m. followed by 20 ppm fluoride for 31 days. Blood sugar level increased in rats given alloxan and alloxan + fluoride. Body weight gain in rats given alloxan + fluoride decreased significantly compared to other groups. Decrease in hemoglobin and glutamic oxaloacetate transaminase (GOT) was seen only in rats given alloxan + fluoride. In this group alkaline phosphatase, the target enzyme in fluoride toxicosis, increased considerably. The toxicity of fluoride in diabetic rats was further reflected in organ weight data. This investigation shows that fluoride toxicity is greater in diabetic rats.
Excerpt:
Pathological findings of the present study also indicate toxicological magnification by fluoride in diabetic rats. Both diabetes and fluorosis are major disorders which affect several organ systems. It may be concluded from the present study that toxicity by fluoride is greater in diabetes.
-
-
Effects of fluoride intake on insulin sensitivity and insulin signal transduction
Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin
-
Topical fluorides: effects on physiologic and biochemical processes
The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in
-
Fluoride impairment of glucose utilization: nature of effect in rats during and after continuous NaF infusion.
Intravenous infusion of 6 mg of fluoride/kg/hr for 3 hr caused a sharp decrease in formation of respiratory 14CO2 from [14C]glucose, regardless of position of the label. Oxidation of [1-14C]fructose was not impaired, indicating that triose metabolism was not hindered; this information, along with the similarity in depression of metabolism
-
Fluoride-induced resistance to insulin in the rat.
The insulinic response of rats challenged with glucose at different times after an oral dose of 40 µmol NaF/100 g bw revealed the concentration of the molecular species reacting with anti-insulin antibody was significantly lower after 3 hr, and the glucose levels were somewhat higher than in controls. At the
-
Activity of pancreatic antioxidative enzymes and malondialdehyde concentrations in rats with hyperglycemia caused by fluoride intoxication.
The aim of this work was to examine the effect of fluoride ions on antioxidative enzyme activity in the pancreas of rats exposed during 4 months to NaF in drinking water. The study was carried out in 30 four-week-old male Wistar FL rats, that were randomly assigned to three equal
Related Studies :
-
-
-
Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
-
Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
-
NRC (2006): Fluoride's Effect on Glucose Metabolism
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific
-
Fluoride Sensitivity Among Diabetics
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions
-
Fluoride & Impaired Glucose Tolerance
The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs
Related FAN Content :
-