Fluoride Action Network

Abstract

Skeletal fluorosis is a rare toxic osteopathy characterized by massive bone fixation of fluoride. The disease occurs as an endemic problem in some parts of the world and is the result of prolonged ingestion or rarely by inhalation of high amounts of fluoride. Radiographic presentation is mainly characterized by bone changes with osteocondensation and later ossification of many ligaments and interosseous membranes. Skeletal fluorosis is not clinically obvious and can be confused with other rheumatologic disorders. Its severity lies in the development of skeletal deformities and neurological complications. Management of fluorosis generally focuses on symptom treatment.

References 

  1. Datta P, Datta PP. Prevalence, etiology and clinical features of skeletal fluorosis: a critical review. Innovare J Med Sci. 2013;1:5–6.Google Scholar

 

  1. Tamer MN, KaleKoroglu B, Arslan C, et al. Osteosclerosis due to endemic fluorosis. Sci Total Environ. 2007;373:43–8.CrossRefPubMedGoogle Scholar

 

  1. Chen J, Liu G, Kang Y, et al. Coal utilization in China: environmental impacts and human health. Environ Geochem Health. 2014;36:735–53.CrossRefPubMedGoogle Scholar

 

  1. Majumdar KK. Health impact of supplying safe drinking water containing fluoride below permissible level on flourosis patients in a fluoride-endemic rural area of West Bengal. Indian J Public Health. 2011;55:303–8.CrossRefPubMedGoogle Scholar

 

  1. Kurdi MS. Chronic fluorosis: the disease and its anaesthetic implications. Indian J Anaesth. 2016;60:157–62.CrossRefPubMedGoogle Scholar

 

  1. Gupta N, Gupta N, Chhabra P. Image diagnosis: dental and skeletal fluorosis. Perm J. 2016;20:105–6.Google Scholar

 

  1. Laatar A, Mrabet D, Zakraoui L. Fluorosis in sub-Saharan Africa. Rev Rhum. 2003;70:178–82.CrossRefGoogle Scholar

 

  1. Guissouma W, Hakamic O, Rajab AJ, Tarhounia J. Risk assessment of fluoride exposure in drinking water of Tunisia. Chemosphere. 2017;177:102–8.CrossRefPubMedGoogle Scholar

 

  1. Reber JD, McKenzie GA, Broski SM. Voriconazole -induced periostitis: beyond post-transplant patients. Skelet Radiol. 2016;45:839–42.CrossRefGoogle Scholar

 

  1. Arlappa N, Aatif IQ, Srinivas R. Fluorosis in India: an overview. Int J Res Dev Health. 2013;1:97–102.Google Scholar

 

  1. Liu Q, Liu H, Yu X, et al. Analysis of the role of insulin signaling in bone turnover induced by fluoride. Biol Trace Elem Res. 2016;171:380–90.CrossRefPubMedGoogle Scholar

 

  1. Pei J, Li B, Gao Y, et al. Fluoride decreased osteoclastic bone resorption through the inhibition of NFATc1 gene expression. Environ Toxicol. 2014;29:588–95.CrossRefPubMedGoogle Scholar

 

  1. Teotia SP, Teotia M, Singh KP (2004) Highlights of forty years of research on endemic skeletal fluorosis in India. 4th International Workshop on Fluorosis Prevention and Defluoridation of Water. Colombo, Sri Lanka; March 2–6.Google Scholar

 

  1. Pramanik S, Saha D. The genetic influence in fluorosis. Environ Toxicol Pharmacol. 2017;56:157–62.CrossRefPubMedGoogle Scholar

 

  1. del Carmen Aguilar-Diaz F, Federico Morales-Corona F, Cintra-Viveiro AC, Fuente-Hernández J. Prevalence of dental fluorosis in Mexico 2005-2015: a literature review. Salud Publica Mex. 2017;59:306–13.CrossRefGoogle Scholar

 

  1. Neurath C, Limeback H, Osmunson B, Connett M, Kanter V, Wells CR. Dental fluorosis trends in US oral health surveys: 1986 to 2012. JDR Clinical and translational Research; 2019. https://doi.org/10.1177/2380084419830957

 

  1. Pendrys DG. The differential diagnosis of fluorosis. J Public Health Dent. 1999;59:235–8.CrossRefPubMedGoogle Scholar

 

  1. Liu J, Fu Z, WU L, Ding H, Wang D-l, YU B-l. The Imaging Value of Bone Turnover of Skeletal Fluorosis. Foreign medical sciences (section of medgeography). 2004;25(2):95–98.Google Scholar

 

  1. Roholm K. Fluorine intoxication: a clinical hygienic study. London: Lewis; 1937.Google Scholar

 

  1. Izuora K, Twombly JG, Whitford GM, Demertzis J, Pacifici R, Whyte MP. Skeletal fluorosis from brewed tea. J Clin Endocrinol Metab. 2011;96:2318–24.CrossRefPubMedGoogle Scholar

 

  1. Bisseret D, Kaci R, Lafage-Proust MH, Alison M, Parlier-Cuau C, Laredo JD, et al. Periosteum: characteristic imaging findings with emphasis on radiologic-pathologic comparisons. Skelet Radiol. 2015;44:321–38.Google Scholar

 

  1. Ramakrishna K, Sasikiran NO. Fluorosis-an update. Int J Res Pharmaceut. Biomed  Sci. 2013;4:1084–8.Google Scholar

 

  1. Subbarao K. Musculoskeletal fluorosis-imaging spectrum. J Med Sci Res. 2013;1:117–23.CrossRefGoogle Scholar

 

  1. Yildiz M, Akdo?an M, Tamer N, Oral B. Bone mineral density of the spine and femur in early postmenopausal Turkish women with endemic skeletal fluorosis. Calcif Tissue Int. 2003;72:689–93.CrossRefPubMedGoogle Scholar

 

  1. Numan Tamer M, Kale Köro?lu B, Arslan C, Akdo?an M, Köro?lu M, Çam H, et al. Osteosclerosis due to endemic fluorosis. Sci Total Environ. 2007;373:43–8.Google Scholar

 

  1. Winn N, Lalam R, Cassar-Pullicino V. Imaging of Paget’s disease of bone. Wien Med Wochenschr. 2017;167:9–17.CrossRefPubMedGoogle Scholar

 

  1. John DR, Suthar PP. Radiological features of long-standing hypoparathyroidism. Pol J Radiol. 2016;81:42–5.CrossRefPubMedGoogle Scholar

 

  1. Jimenez-Garcia R, del Barrio J, Hernandez-Barrera V, Miguel-Díez J, Jimenez-Trujillo I, Martinez-Huedo M. Is there an association between diabetes and neck pain and lower back pain? Results of a population-based study. J Pain Res. 2018;11:1005–15.CrossRefPubMedGoogle Scholar

 

  1. Kumar H, Boban M, Tiwari M. Skeletal fluorosis causing high cervical myelopathy. J  Clin Neurosci. 2009;16:828–30.CrossRefPubMedGoogle Scholar

 

  1. Wang W, Kong L, Zhao H, et al. Thoracic ossification of ligamentum flavum caused by skeletal fluorosis. Eur Spine J. 2007;16:1119–28.CrossRefPubMedGoogle Scholar

 

  1. Di Giovanni T, Eliades T, Papageorgiou SN. Interventions for dental fluorosis: a systematic review. J Esthet Restor Dent. 2018;30:502–8.Google Scholar

 

  1. Khairnar MR, Dodamani AS, Jadhav HC, Naik RG, Deshmukh MA. Mitigation of fluorosis—a review. J Clin Diagn Res. 2015;9:ZE05–9.PubMedGoogle Scholar