Abstract
Purpose: This study investigated the potential association between fluoride exposure and behavior problems in children, as well as the prevalence of and risk factors for fluorosis.
Methods: Children between the ages of 7 and 1 years (N = 197) were included in the study and were examined for dental fluorosis using the Modified Dean’s Index. Parents of subjects completed and returned three questionnaires which investigated their children’s history of exposures to fluoride, social and medical backgrounds, and behavior using the Child Behavior Checklist (CBCL).
Results: Sixty-nine percent of the study participants demonstrated fluorosis with very mild fluorosis being the most common (39%), while 13% demonstrated moderate to severe fluorosis. Using a summation of the Modified Dean’s index (Sum of 8), we divided the children into high fluorosis (HF) and low fluorosis (LF) groups. These groups were compared to each other with respect to fluoride exposures and behavior.
Conclusion: Although there was no association between the fluoride exposures in aggregate and fluorosis, there was a significant association between supplemental fluoride exposure from ages 0-3 years and fluorosis. There was no association between behavior problems and dental fluorosis in this population.
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Influence of fluoride exposure on reaction time and visuospatial organization in children
Note: This is a conference abstract from the 2000 Annual Conference of the ISEE (International Society for Environmental Epidemiology). No full study has been published. Fluoride exposure is an important public health problem in several Mexican states. In the city of San Luis Potosi, Mexico, above 90% of the children have
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Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice
Background: Neonatal exposure to anesthetics that block Nmethyl D-aspartate receptors and/or hyperactivate -aminobutyricacid type A receptor has been shown to cause neuronal degeneration in the developing brain, leading to functional deficits later in adulthood. The authors investigated whether exposure of neonatal mice to inhaled sevoflurane causes deficits in social behavior
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Effects of fluoride on psychomotor performance and memory of aluminum potroom workers
In this cross-sectional study, the psychomotor performance and memory skills of a fluoride-exposed group (FEG) of 64 male workers in an aluminum potroom were compared with those of 60 male workers in a nonfluoride-exposed group (NFEG). The FEG had a mean age of 37.59±4.82 yr and had been employed for
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Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway.
Depression is a mental health problem with typically high levels of distress and dysfunction, and 150 mg/L fluoride (F) can induce depression-like behavior. The development of depression is correlated with neuronal atrophy, insufficient secretion of monoamine neurotransmitters, extreme deviations from the normal microglial activation status, and immune-inflammatory response. Studies found
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Research on the neurobehavioural function of workers occupationally exposed to fluoride.
Sixty-five operations workers (all males) in an electrolytic aluminum production facility were divided into two groups. The first group of 37 was employed for more than 5 years, and the second group of 28 for 5 years or less. These men had no history of liver, kidney, or immune-related disease. X-ray tests indicated that they were not suffering
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Diagnostic Criteria for Dental Fluorosis: The TSIF ("Total Surface Index of Fluorosis")
The traditional criteria (the "Dean Index") for diagnosing dental fluorosis was developed in the first half of the 20th century by H. Trendley Dean. While the Dean Index is still widely used in surveys of fluorosis -- including the CDC's national surveys of fluorosis in the United States -- dental
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Dental Fluorosis Impacts Dentin in Addition to Enamel
Dental fluorosis is a mineralization defect of tooth enamel marked by increased subsurface porosity. The enamel, however, is not the only component of teeth that is effected. As several studies have demonstrated, dental fluorosis can also impair the mineralization of dentin as well. As noted in one review: "The fact that
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Fluoride's Effect on Fetal Brain
The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts
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Mechanisms by Which Fluoride Causes Dental Fluorosis Remain Unknown
When it comes to how fluoride impacts human health, no tissue in the body has been studied more than the teeth. Yet, despite over 50 years of research, the mechanism by which fluoride causes dental fluorosis (a hypo-mineralization of the enamel that results in significant staining of the teeth) is not
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Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
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