Abstract
In 4 settlements in Israel girls, 2685 in all and aged 7 to 18 years included 17, 30, 4.7 and 2.6% with goitre. In the corresponding water supplies I was, <2, 4 5 to 65, 8 to 100 and 20 µg and F, <0.1, 0 to 0.3, 0.65 to 0.9 and 0.3 mg per litre. F did not appear to affect thyroid function. For earlier work see Abst. 4185, Vol. 31. A. Hepburn.
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Lack of effect of fluorine ingestion on uptake of iodine 131 by the thyroid gland.
No abstract available
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Pathological changes in the tissues of rats (albino) and monkeys (macaca radiata) in fluorine toxicosis
1. Stomach, duodenum, small intestine, kidney, liver, spleen, skin, heart, aorta, lungs, brain, pancreas, adrenals, thyroid and parathyroid of rats and monkeys suffering from chronic fluorosis have been histologically examined. 2. Fluorine has not been found to have any effect on the heart muscle, aorta, skin and parathyroids, whereas it has
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The synergistic action of thyroid on fluoride toxicity
Control rats on the basic diets employed developed normal or nearly normal incisor teeth. Rats on the same basic diets to which dried thyroid had been added developed incisor teeth that were markedly bleached due to a potentiation of the toxic action of the fluorine in the basic diet. Subcutaneous
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Fluoride-induced thyroid proliferative changes and their reversal in female mice and their pups.
To determine effects of fluoride on thyroid function in suckling mice, adult female mice were given 500 ppm NaF (226 ppm F–) in their drinking water from the 15th day of pregnancy until either the 4th or 14th day after parturition. On day 14 of full-period treatment, pups and their
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Effect of fluorine on thyroidal iodine metabolism in hyperthyroidism.
Prolonged administration of a daily dose of 5-10 mg. of fluoride to patients with hyperthyroidism may cause clinical improvement together with a significant fall in the level of plasma protein-bound iodine and a reduction in the basal metabolic rate. Studies with radioactive fluorine failed to demonstrate any important accumulation of
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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Fluoride Aggravates Thyroid Damage Caused by Excess Iodine Intake
Chinese researchers have found that the combination of excess fluoride with excess iodine caused greater reductions in IQ, or greater increases in goitre than either scenario by itself.
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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