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Factors which increase the risk for skeletal fluorosis
The risk for developing skeletal fluorosis, and the course the disease will take, is not solely dependent on the dose of fluoride ingested. Indeed, people exposed to similar doses of fluoride may experience markedly different effects. While the wide range in individual response to fluoride is not yet fully understood, the following are some of the factors that are believed to play a role.
Genetic Susceptibility to Fluoride
“The results suggest that genetic factors may contribute to the variation in bone response to fluoride exposure…. The genetic influence on the efficacy and adverse effects has been demonstrated for some medications but has never been demonstrated for bone response to fluoride. The demonstration of such genetic influence on bone response to fluoride has important […]