Abstract
Eighty two children, aged 8 – 13 years old, from Wamiao village (severe endemic fluorosis area), from Xinhuai village (nonendemic fluorosis area) were 88 (as a control group), were recruited in this study. The prevalence of dental fluorosis (DF) were 85.37% (Wamiao) and 6.82% (Xinhuai) in two village’s children respectively; drinking water fluoride (F-) in children’s household shallow well from 0.62 – 4.00 mg/L in Wamiao and 0.23 – 0.76 mg/L in Xinhuai; serum total triiodothyronine (TT3), total thyronine (TT4), thyroid-stimulating hormone (TSH) were 1.47 ± 0.28 and 1.47 ± 0.33 ng/mL, 9.67 ± 1.76 and 9.22 ± 2.54 mg/dL, 3.88 ± 2.15 and 2.54 ± 2.07 mIU/mL in two villages children respectively. The prevalence of DF, drinking water F-, serum TSH in Wamiao village was significantly higher than that in Xinhuai village. As the children in Wamiao village were divided into different subgroups according to their severity of DF, serum TT3 and TSH showed significant difference in different groups. The results in this study confirmed that the high F- exposure can caused functional abnormalities of thyroid, and the different severity degree of DF may be relation to significant deviation in the serum levels of thyroid hormone.
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[The change of thyroid functlon from the children with fluoride aluminum combined toxicosis in Shuicheng Area of Guizhou].
The levels of serum T3, T4 and TSH were analyzed in the children with fluoride aluminum combined toxicosis in Shuicheng area of Guizhou as compared with the children without fluoride-aluminum combined toxicosis. The results showed that serum T4 content decreased in the children with fluoride aluminum combined toxicosis (103.9±15.9 nmol/L
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Impact of Drinking Water Fluoride on Human Thyroid Hormones: A Case- Control Study.
The elevated fluoride from drinking water impacts on T3, T4 and TSH hormones. The aim was study impacts of drinking water fluoride on T3, T4 and TSH hormones inYGA (Yazd Greater Area). In this case- control study 198 cases and 213 controls were selected. Fluoride was determined by the SPADNS
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Effects of fluoridated water on tissues of CSE female mice
Evidence suggests that certain tissues of the body are affected by inorganic fluoride in the diet. Groups of CSE female mice received different concentrations of fluoride in their drinking water for approximately 26 weeks. Slight variation in water and food intake was observed among the groups. Histological observation revealed pathological
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A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas.
Abstract The study was undertaken to determine serum/urinary fluoride status and comparison of free T4, free T3 and thyroid stimulating hormone levels of 8 to 15 years old children with and without dental fluorosis living in an endemic and non-endemic fluorosis area. A sample group of 60 male and female school children,
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Functional state of thyroid under extended exposure to fluorides
The issue of specific effect of fluorine on the thyroid in humans remains debatable. There is no doubt, however, that cases of experimental fluorosis are characterized by specific toxicity of fluorine to the thyroid. The hypoactivity of thyroid epithelium is observed, the destructive changes in the follicular cells increasing with the
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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