Abstract
A chronic intake of fluoride through food and drinking water is also known to cause hyperglycemia and dyslipidemia besides fluorosis. The present study deals with the effects of fluoride (100 ppm) induced hyperglycemia and dyslipidemia and the alleviatory potential of Mangifera indica L. on the carbohydrate and lipid profiles in laboratory rats. Exposure to fluoride resulted in significant elevation in plasma glucose, hepatic glucose-6-phosphatase, plasma and hepatic lipid profiles and a reduction in plasma HDL-C, hepatic glycogen content and hexokinase activity. Inclusion of different doses of M. indica fruit powder (2.5, 5 and 10 gm%) in the basal diet brought about a dose- dependent reversal of diabetes like complications, i.e., a significant reduction in plasma glucose, increase in glycogenesis and decrease in glyconeogenesis in the treatment groups. All the three doses also decreased the hyperlipidemic status by reducing the plasma and hepatic total lipids, total cholesterol, triglycerides, plasma low & density lipoprotein cholesterol, very low-density lipoprotein cholesterol with a concurrent increase in high-density lipoprotein cholesterol contents. Therefore, it is concluded that M. indica fruit powder as a food supplement can reduce the fluoride induced hyperglycemia and hyperlipidemia.
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Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat.
The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and
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Correlation between serum fluoride and hyperglycemia in endemic fluorosis area
As fluoride inhibits Glycolysis we conducted a preliminary study to analyse the effect of fluoride on blood glucose in the individuals of endemic fluorosis area . The study was conducted to correlate the serum fluoride with blood glucose levels in a population living in endemic fluorosis area The present study included serum
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Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations
OBJECTIVES: Fluoride is a serious health hazard across several nations, and chronic intake of fluoride deranges the carbohydrate, lipid and antioxidant metabolism in general. As there are limited remedial measures to prevent fluorosis, we investigated the role of tamarind leaf as a food supplement in restoration of carbohydrate, lipid and
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[Changes in bone mass and in glucose homeostasis in subjects with high spontaneous fluoride intake]
This paper reports metabolic data of 24 women and two men, 44-66 years old, ex-residents in an area of endemic fluorosis close to Bahía Blanca city. Fasting fluoremias of these subjects (0.5 to 9.2 microM) and daily urinary fluoride excretion (> 60 mumoles/day) are characteristics of zones with endemic fluorosis.
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Effect of F on rat serum insulin levels in vivo
Several investigators have shown an acute administration of NaF in rats can induce a hyperglycemia. The current study was undertaken to determine if acute injections of NaF would alter the serum insulin levels since LIN et al., Horm. Metab. Res 8, 353-358, 1976 had shown that NaF could inhibit the
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Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Fluoride & Impaired Glucose Tolerance
The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs
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Fluoride Sensitivity Among Diabetics
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions
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NRC (2006): Fluoride's Effect on Glucose Metabolism
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific
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