Abstract
1. Fluoride toxicosis was induced in young rats of the Long-Evans strain. Ten rats received a total of 406.47 mg. each of sodium fluoride injected intraperitoneally over a fifteen-day period, to induce acute poisoning. Seven rats survived, of which six were analyzed for this study. Ten others received a total of 1131.65 mg. each in 100 days, under which chronic regimen five survived.
2. Weight gain of the animals, their appearance, and the gross structure of the liver, kidney, pancreas, adrenal, and thyroid were not significantly different from those in the sodium chloride-injected controls.
3. Histologically, the kidney was the site of greatest damage and showed interstitial edema, tubular destruction, and hyperemia (glomerular and medullary). The pancreas showed increased width of connective tissue septa and evidence of increased mitosis of acinar cells. The thyroid gland was mildly atrophic. In the acutely fluorosed rats there was evidence of adrenal cortical hypertrophy, and the adrenal gland weight was increased in both groups. The liver remained histologically unchanged.
-
-
Pathological changes in the tissues of rats (albino) and monkeys (macaca radiata) in fluorine toxicosis
1. Stomach, duodenum, small intestine, kidney, liver, spleen, skin, heart, aorta, lungs, brain, pancreas, adrenals, thyroid and parathyroid of rats and monkeys suffering from chronic fluorosis have been histologically examined. 2. Fluorine has not been found to have any effect on the heart muscle, aorta, skin and parathyroids, whereas it has
-
Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats
Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been some speculation that excess fluoride could cause an impact on genome integrity. In the current study, the potential DNA damage associated with exposure to fluoride was assessed in cells of blood, liver, kidney, thyroid
-
Deterioration of renal function in ICR-derived glomerulonephritis (ICGN) mice by subacute administration of fluoride in drinking water.
Sodium fluoride was administered at 0, 25, 50, 100, and 150 ppm F in drinking water for 4 weeks to Institute of Cancer Research (ICR) derived glomerulonephritis (ICGN) mice. Fluoride was also administered to ICR mice at 0 and 150 ppm. Blood was sampled from the tail artery of each
-
Necessity to Pay Attention to the Effects of Low Fluoride on Human Health: an Overview of Skeletal and Non-skeletal Damages in Epidemiologic Investigations and Laboratory Studies.
Due to the implementation of water improvement and fluoride reduction plans supported by central and local governments in recent years, areas with high fluoride exposure are being gradually decreased. Therefore, it is of practical importance to study the effect of low fluoride on human health. Epidemiologic investigations and in vivo
-
Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in antioxidant status of heart, liver, and kidney of rats
Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart,
Related Studies :
-
-
-
NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
-
Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
-
Fluoride Gels & Kidney Function
Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each
-
Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
-
Fluoride as a Cause of Kidney Disease in Humans
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing
Related FAN Content :
-