Abstract
Gastroscopy to 35 patients with fluorosis, 32 with arsenic-fluorosis, and 25 control had been performed to study the influence of fluorosis on arsenic-fluorosis on the gastric mucosa. There was significant difference on gradient and activity of chronic gastritis among the three groups, but there was no significant difference in the fluorosis and arsenic-fluorosis [groups]. It appears that pathological changes of gastric mucosa of fluorosis and arsenic-fluorosis may be caused only by fluorosis.
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Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride.
Many “hot spot” geographic areas across the world with drinking water co-contaminated with inorganic arsenic (iAs) and fluoride (F-), two of the most common natural contaminants in drinking water. Both iAs and F- are known neurotoxins and affect neurodevelopment of children. However, very few studies have investigated the neurodevelopmental effects
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Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats.
Highlights Co-exposure to arsenic and fluoride leads to adverse cardiovascular effects. Co-exposure to arsenic and fluoride results in gut microbiota perturbations. Co-exposure causes more prominent effects than arsenic or fluoride alone. Strong correlations are identified between cardiovascular effects and significantly altered genera. Co-exposure to inorganic arsenic (iAs) and fluoride (F-)
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Fluoride exposure is associated with altered metabolism of arsenic in an adult Mexican population.
Highlights Co-occurrence of As and F was found in water and urine samples. Interactions between the exposure of As and F on arsenic metabolism in humans were found. Interaction terms show increased MAs% and decreased DMAs% and As methylation indices. F exposure may modify the As metabolism profile, in low-moderate
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Co-exposure to Arsenic-Fluoride Results in Endoplasmic Reticulum Stress-Induced Apoptosis Through the PERK Signaling Pathway in the Liver of Offspring Rats.
Arsenic and fluoride are two of the major groundwater pollutants. To better understand the liver damage induced during development, 24 male rats exposed to fluoride (F), arsenic (As), and their combination (As + F) from the prenatal stage to 90 days after birth were selected for analysis. Histopathological results showed
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Combined effect of arsenic and fluoride at environmentally relevant concentrations in zebrafish (Danio rerio) brain: Alterations in stress marker and apoptotic gene expression.
Highlights Arsenic and fluoride are the most common hazardous contaminant in the environment. Histological anomalies and alteration of oxidative stress parameters were evident. Stress responsive and apoptotic genes showed less pronounced effects upon co-exposure. DNA ladder was found in both individual treatment, not in combined. Elemental analysis and as3mt
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
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Side Effects from Fluoride Gels: Gastric Distress
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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