Abstract

The rates of urine flow and the plasma fluoride concentrations were measured in anesthetized rats receiving continuous infusions of graded levels of fluoride in isotonic solutions. Infusion of 500 nmoles of fluoride/min produced the maximum diuresis, three times the mean control urine flow rate, and a plasma fluoride concentration of 272 ?M. The 100 nmoles/min fluoride infusion rate produced an 80% increase in urine flow rate with a plasma fluoride concentration of 56 ?M. These findings are consistent with estimates made for man and with the suggestion that the nephrotoxicity following methoxyflurane anesthesia is at least in part due to metabolism of methoxyflurane to inorganic fluoride.

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