Abstract
The topical application of sodium fluoride to abraded rat skin produced several morphological and biochemical effects. Related to the degranulation of dermal mast cells, skin histamine concentration was increased, fluorides were absorbed into the skin, and deposited mainly kin mitochondria. Dermal histamine binding was decreased for both H1 and H2 receptors with reduced binding sites, but epidermal adenyl cyclase was activated by fluorides. The response of the rat skin to fluorides involves a sequence of changes by which the potentiation of an inflammatory response also involves alterations in specific histamine receptors and a histamine-specific adenyl cyclase system.
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The effect of stannous fluoride and stannous chloride on inflammation
Scratches were made to the depth of the upper dermis on the abdomen of rabbits. The scratches were covered by patch tests for 18 hours with solutions of stannous fluoride or stannous chloride. Both these substances produced a destructive reaction with intraepidermal polymorphonuclear leukocyte pustules occurring on each side of
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Contact urticaria from sodium fluoride
Sodium fluoride (NaF) is. used for the treatment and prevention of dental caries. Its application to the teeth makes the dental enamel more resistant to acid. In some communities, it is added to the water if the geographical area lacks sufficient fluoride. Another method of preventing dental caries is the
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Perioral dermatitis from high fluoride dentifrice: a case report and review of literature
Perioral dermatitis is a papulopustular eruption, commonly related to the inappropriate application of topical corticosteroids with occasional reports of inhaled corticosteroids and decreased personal hygiene. We present a case of a 45-year-old female with a one-year history of perioral dermatitis related to the use of highly fluoridated toothpaste commenced to
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Enhancement of inflammation by fluorides
Application of ammonium fluoride under an occlusive patch to the abdomen of a rabbit converts a simple scratch into a double row of sterile pustules. Sodium fluoride produces a similar response, but ammonium chloride does not produce pustules. . . . It appears that tissue damage and the presence of fluorides
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Fluoroderma
Papulonodular eruptions from certain bromide and iodide preparations are widely recognized entities, but skin lesions following fluoride ingestion are rare. Modern prophylaxis for postirradiation dental caries includes the use of fluoride gel preparations applied to the teeth. In two patients receiving such therapy a papulonodular eruption developed, similar to the
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Physician's Desk Reference: Fluoride Hypersensitivity
The following are excerpts from various editions of the Physicians' Desk Reference (PDR). "In hypersensitive individuals, fluorides occasionally cause skin eruptions such as atopic dermatitis, eczema or urticaria. Gastric distress, headache and weakness have also been reported. These hypersensitivity reactions usually disappear promptly after discontinuation of the fluoride. In rare cases,
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Fluoride Dentrifice and Stomatitis
Statistical data of 133 patients who have been using fluoride dental cream or powder have been presented. Each has developed intraoral ulcerative lesions. Many have been treated for other complaints without clearance of the lesions. Age is not significant. Repeated insults with the fluoride dentrifices produced increasingly severe excoriations. There seems to be nothing specific about the lesions to differentiate them from other diseases of an oral nature.
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Allergy and Hypersensitivity to Fluoride
there are reasonable grounds for concluding that there are individuals in whom allergy or hypersensitivity to fluoride has been demonstrated.
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Allergy to Fluoride
Six children and one adult exhibited various allergic reactions after the use of toothpaste and vitaimin preparations containing fluoride. The following conditions were encountered: Urticaria, exfoliative dermatitis, atopic dermatitis, stomatitis, gastro-intestinal and respiratory allergy.
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Fluoride Toothpaste: A Cause of Acne-like Eruptions
I feel that I should share with my colleagues in dermatology an observation relative to the treatment of problem acne.
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