Abstract
Fluoride has been considered to cause hepatic and renal tissue damages in animals and humans. The present study investigated the effect of varying concentrations of fluoride on hepatic and renal enzyme profile in domestic chicken (n= 80). Chickens were distributed into 4 groups. Group A was kept unexposed while group B, C and D were exposed to 10, 20 and 30 ug/g bod y weight of NaF respectively on weekly basis for four weeks. Alkaline p hosphatase (ALP), a spartate a minotransferase (AST), a lanine amino – t ransferase (ALT) and bilirubin were determined as indicators of liver function test (LFT), while uric acid was as a parameter for renal f unction test (RFT). All LFT and RFT parameters showed high values (P< 0.05) after one, two, three and four weeks in all groups. 579.4 ± 1.55, 355.0 ± 2.13, 246.2 ± 2.45 and 0.83 ± 1.46 were the ALP, AST, ALAT and bilirubin values for LFT and uric acid was 6.74 ± 2.92 in D group at the end of four weeks. All these results indicate the probability of severe effect on the physiology of the liver and kidneys in the exposed birds .
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Induction of oxidative stress on reproductive and metabolic organs in sodium fluoride-treated male albino rats: protective effect of testosterone and vitamin E coadministration
The present study was undertaken to search out the effect of sodium fluoride, a water pollutant noted throughout the world, including India, on oxidative stress induction in reproductive tissues, sperm pellet, and metabolic tissues like the liver and kidney. The protective effects of testosterone or vitamin-E coadministration were also observed
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Studies on effects of fluoride in 36 villages of Mehsana District, North Gujurat"
A survey was carried out in 36 fluoride endemic villages of Mehsana District of North Gujarat. Urine and blood samples of fluoride-afflicted human population and their drinking water were analysed for fluoride content and compared with samples from different parts of Ahmedabad city (control). The fluoride content in water samples
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Conceivable amelioration of NaF-induced toxicity in liver, kidney and brain of chicken by black tea extract: an in vitro study.
Sodium fluoride (NaF) toxicity on enzymatic and non-enzymatic oxidative stress markers of chicken liver, kidney and brain homogenate in in vitro condition where studied in present investigation. We studied alteration in the activity of superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (LPO) and glutathione (GSH) content to study oxidative stress.
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Histological and histochemical appearance of livers and kidneys of rats after long-term treatment with different concentrations of sodium fluoride in drinking water
After a review of the controversies in the literature, a histologic and histochemical study of the livers and kidneys of 48 albino rats was performed. The animals were placed on a diet containing 1 ppm NaF in demineralized drinking water, or 1, 10 or 100 ppm NaF in tap water
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Study on changes of clinical indicators and key proteins from fluoride exposure
Few studies have evaluated the biomarker changes of fluoride exposure. In order to explore early and sensitive indicators, animal experiment was designed. Ninety-six healthy SD rats (48 males and 48 females) weighing approximately 60 g were randomly divided into six groups of 16 animals each by gender average. Control animals
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Kidney: A potential target for fluoride toxicity
The kidneys are the organ responsible for clearing fluoride from the body. In the process of doing so, the kidneys are exposed to concentrations of fluoride that exceed, by a factor of 50, the concentration of fluoride in human blood. As such, the kidney have long been considered a potential
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Fluoride as a Cause of Kidney Disease in Humans
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing
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Fluoride Gels & Kidney Function
Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each
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Fluoride & Kidney Stones
It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium
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Fluoride as a Cause of Kidney Disease in Animals
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing in
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