Abstract
Eight 14-week-old male Wistar FL strain rats were administered sodium fluoride in a single intraperitoneal dose (35 mg NaF/kg of bw). After 90 min the rats were fatally anesthetized with ether, and blood samples were taken. Compared to ten control rats, fluoride-treated rats developed hyperglycemia accompanied by a statistically significant increase in the concentration of fluoride, creatinine, and urea and a decrease in the level of protein and calcium in the blood serum. The results indicate disturbances in the filtrating function of kidneys in rats.
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Serum kinetics of ionized fluoride and abnormalities of urinary parameters after single intravenous injection of hydrofluoric acid in rats.
Harmful systemic effects were studied 1 hour after acute sub-lethal exposure to hydrofluoric acid (HFA) in previous study. This study was designed to investigate the early dynamic state of F in blood and urine in rats as a model of accidental occupational exposure to HFA. It was also designed to
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Renal osteodystrophy in patients on long-term hemodialysis with fluoridated water
Serum and bone fluoride concentrations of ten patients maintained on long-term hemodialysis with fluoridated water (1 ppm, i.e., 50uM) were correlated with duration of treatment and the occurrence of clinical, radiological, and histological manifestations of bone disease. Two patients had symptomatic renal osteodystrophy when accepted on the program, whereas six
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Hemodialyzability of ionizable fluoride in hemodialysis session
The fluoride ion content in serum and in dialysate medium was determined by means of a fluoride ion-selective electrode in 29 patients undergoing hemodialysis treatment. Abnormally high serum fluoride of 65.9 +/- 28.3 microg l(-1) at the beginning and 46.5 +/- 26.7 microg l(-1) at the completion of the hemodialysis
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Serum ionic fluoride concentrations are related to renal function and menopause status but not to age in a Japanese general population
BACKGROUND: There have been no studies in which fasting serum ionic fluoride (SIF) concentrations in a general population were investigated despite the fact that SIF has various activities in humans. METHODS: A total of 332 healthy subjects (167 men and 165 women aged 40 to 69years) were selected from residents of
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Studies on serum fluoride and bone metabolism in patients with long term hemodialysis
With growing experience of the long-term treatment of patients with end stage renal disease by hemodialysis, the safety of fluoridated water supply for dialysate and the effect on the bone metabolism has been discussed. In this study, concentrations of fluoride (F), calcium (Ga). aluminum (AI) and biochemical indices of bone metabolism,
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