Abstract
This study is comprised of 106 male patients over age forty from a high fluoride water (3.5-12.5 ppm) area. These patients have been matched by age and sex with 106 patients from a low fluoride water (0.00-0.45 ppm) area.
All patients had radiograms of the chest, pelvis and both femora; 21 in the fluorotic group underwent a skeletal survey. All plain films were examined for skeletal fluorosis changes; pelvis and femur radiograms for Moenckberg arterial calcifications.
Over age 60, patients in the high-fluoride group showed a significantly higher incidence of Moenckberg calcifications. A highly significant correlation (p < 0.001) was observed between the severity of these calcifications and the severity of skeletal changes within this group.
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Histological and chemical studies in man on effects of fluoride
The presence of elevated concentrations of fluorides in the atmosphere has been associated with changes in certain plants and an increase in the fluoride content of forage in certain areas in Utah. Long-term ingestion of such forage by some animals has produced changes characteristic of fluorosis in some of them.
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Fluoride and calcium levels in the aorta
Among soft tissue organs which store fluoride (F-), the aorta contains the highest levels. [1-2]. Calcifications of arteries of the Monckeberg type have been reported in relatively young persons afflicted with skeletal fluorosis from endemic areas. [3-5] It was, therefore, of interest to determine whether or not there is a
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Association of vascular fluoride uptake with vascular calcification and coronary artery disease
Objective: The feasibility of a fluoride positron emission tomography/computed tomography (PET/CT) scan for imaging atherosclerosis has not been well documented. The purpose of this study was to assess fluoride uptake of vascular calcification in various major arteries, including coronary arteries. Methods: We retrospectively reviewed the imaging data and cardiovascular history of
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Aortic calcification in chronic fluoride poisoning: biochemical and electronmicroscopic evidence
Fluoride is known to cause ectopic calcification. The biochemical mechanism(s) involved in the initiation of calcification is not understood and the accompanying ultrastructural changes remain to be elucidated. Therefore, certain relevant parameters have been investigated in the aorta of rabbits administered fluoride, 10 mg NaF/kg body wt, every 24 hr
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Effect of water fluoridation on the development of medial vascular calcification in uremic rats
Public water fluoridation is a common policy for improving dental health. Fluoride replaces the hydroxyls of hydroxyapatite, thereby improving the strength of tooth enamel, but this process can also occur in other active calcifications. This paper studies the effects of water fluoridation during the course of vascular calcification in renal
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Fluoride, Blood Pressure and Hypertension
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