Abstract

Three cases are reported in which fluoride was administered to individuals with osteoporosis. Bone biopsies taken after 7 to 24 months of therapy show that the effect of fluoride on bone tissue appears to be stimulation of new bone formation. If calcium and vitamin D are not administered with the fluoride, the new bone is largely uncalcified; however, if an increase in calcium absorption is produced, then the new bone tissue appears relatively normal.

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