Conclusion:
1. During the treatment with a total dose of 21 grams of fluoride in a two years period further compression fractures of vertebrae were noticed in 5 or 23 cases. No conclusion can be drawn of course from further compression fractures about the effectiveness of treatment. Concerning the peripheral skeleton an average decrease of the bone mineral content of the radius was observed.
2. The histological picture of the bone biopsies show on an average a positive influence of treatment after the mentioned dose and time.
3. Taking into consideration all parameters, an analysis of the individual cases shows a progression in 4 cases, an obvious amelioration of osteoporosis in 6 cases and in 13 cases nearly unchanged findings indicate no progression of the disease.
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Fluoride pharmacokinetics and changes in lumbar spine and hip bone mineral density
Debate about the use of fluoride for the treatment of vertebral osteoporosis has centered not only on whether fluoride treatment decreases vertebral fractures, but also the interindividual vertebral bone mineral density (BMD) response, the potential for nonvertebral fractures, as well as side effects and tolerability. These effects may be dose
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Fluoride exposure and bone status in patients with chronic intestinal failure who are receiving home parenteral nutrition
BACKGROUND AND OBJECTIVE: Metabolic bone disease is frequent in chronic intestinal failure. Because fluoride has a major effect on bones, the status of both fluoride and bone was studied in long-term home parenteral nutrition (HPN) patients. DESIGN: We studied 31 adults aged (x +/- SD) 56.3 +/- 15.1 y, mainly
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Fluoridation and the rheumatic diseases: a comparison of rhematism in Watford and Leigh
(1) A population sample in the town of Watford, Hertfordshire, has been examined clinically, radiologically, and serologically to determine the prevalence of chronic rheumatic diseases. A comparison has been made with a population sample in Leigh, Lancashire. The water supply in Watford had been fluoridated during the previous 5 years,
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The effect of sodium fluoride on trabecular architecture
The effect of sodium fluoride therapy on iliac trabecular bone has been studied in 15 patients with primary osteoporosis by comparing bone biopsies taken before and after two years of treatment. A marked increase in bone volume (43%) was observed, which was attributable to an increase in trabecular thickness (46%)
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The response of vertebral bone mineral density during the treatment of osteoporosis with sodium fluoride
Forty-eight female patients with postmenopausal osteoporotic vertebral compression fractures were treated with sodium fluoride and calcium supplements; their response to treatment was documented by sequential measurements of vertebral and forearm bone mineral density (BMD). During treatment 25 patients developed significant side-effects due to fluoride, and ultimately, 18 patients (37%) were
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