Conclusion:
1. During the treatment with a total dose of 21 grams of fluoride in a two years period further compression fractures of vertebrae were noticed in 5 or 23 cases. No conclusion can be drawn of course from further compression fractures about the effectiveness of treatment. Concerning the peripheral skeleton an average decrease of the bone mineral content of the radius was observed.
2. The histological picture of the bone biopsies show on an average a positive influence of treatment after the mentioned dose and time.
3. Taking into consideration all parameters, an analysis of the individual cases shows a progression in 4 cases, an obvious amelioration of osteoporosis in 6 cases and in 13 cases nearly unchanged findings indicate no progression of the disease.
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Deterioration of teeth and alveolar bone loss due to chronic environmental high-level fluoride and low calcium exposure
OBJECTIVES: Health risks due to chronic exposure to highly fluoridated groundwater could be underestimated because fluoride might not only influence the teeth in an aesthetic manner but also seems to led to dentoalveolar structure changes. Therefore, we studied the tooth and alveolar bone structures of Dorper sheep chronically exposed to
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Associations of fluoride intake with children's cortical bone mineral and strength measures at age 11.
OBJECTIVES: There is strong affinity between fluoride and calcium, and mineralized tissues. Investigations of fluoride and bone health during childhood and adolescence show inconsistent results. This analysis assessed associations between period-specific and cumulative fluoride intakes from birth to age 11, and age 11 cortical bone measures obtained using peripheral quantitative
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The effect of pregnancy and lactation on bone mineral density in fluoride-exposed rats
Fluoride increases metabolic turnover of the bone in favour of bone formation. Excessive intake of fluoride may lead to pathological changes in teeth and bones: dental and skeletal fluorosis. In this study, we investigated the effect of pregnancy and lactation on bone mineral density (BMD) in fluoride-exposed rats. Female Wistar
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Newburgh-Kingston caries-fluorine study. XIII. Pediatric findings after ten years
The onset of menstruation in girls was selected as an index of the rate of sexual maturation, since the menarche is an event which is usually readily dated. The distribution of ages at the nearest birthday at which menstruation first occurred is shown in Table 5. The average age at
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Fluoride intake and bone measures at age 5
Fluoride intake is known to affect mineralization of both teeth and bones. Few studies have comprehensively assessed fluoride intake and related findings to bone measures. Objectives: To relate fluoride intake from birth to age 4 years to bone measures (spine bone mineral content [bmc] and density [bmd], hip bmc and
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"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
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Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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