Abstract
Effects on Ca++ translocation and [Ca++]i were studied in dog thyroïd cell monolayers using both 45Ca++ efflux and the indicator quin-2. Carbamylcholine, a non hydrolysable analog of acetylcholine, through muscarinic receptors, and to a lesser extent TRH and PGF2 alpha increased both these parameters. [Ca++]i increased by 171, 100 and 75% respectively over a basal level of 66 +/- 17 nM (mean +/- SD). The response to carbamylcholine was biphasic. A transient increase in [Ca++]i was followed by a more sustained phase where the [Ca++]i was slightly higher than the basal level. Only the first phase was insensitive to extracellular Ca++ depletion. This phase is probably due to a release of Ca++ from an intracellular store. NaF also induced a sustained rise in [Ca++]i dependent on extracellular Ca++ and affected 45Ca++ efflux. Our data provide direct evidence of an implication of intracellular Ca++ in the response of dog thyroïd cells to all these agents.
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Effect of sodium fluoride on the thyroid follicular cells and the amelioration by calcium supplementation in albino rats: A Light And An Electron Microscopic Study
Sodium fluoride was the first fluoride compound used in the fluoridation of drinking water and it is still commonly used for that purpose to prevent dental caries. It exerts toxic effects on many soft tissues and organs. The thyroid gland has a strong capacity for absorbing and accumulating fluoride. Objective: The
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Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level.
To assess the roles of dietary protein (Pr) and calcium (Ca) level associated with excessive fluoride (F) intake and the impact of dietary Pr, Ca, and F on thyroid function, 144 30-day-old Wistar albino rats were randomly allotted to six groups of 24 (female:male = 1:1). The six groups were
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[Effects of fluoride on the thyroid morphology and thyroid peroxidase and serum thyroid hormones].
Objective To observe the effects of fluoride on thyroid morphology,thyroid peroxidase and serum thyroid hormones. Methods One - month ablactating SD rats were randomly divided into three groups:the control group, low-fluoride group, middle-fluoride group, high-fluoride group, fed with water containing different fluoride concentration by adding NaF respectively. Rats were sacrificed after
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Effects of fluoride on metamorphosis, thyroid and skeletal development in Bufo gargarizans tadpoles
This study examined the effects of chronic fluoride exposure on metamorphosis, thyroid and skeletal development in tadpoles of Chinese Toad, Bufo gargarizans. The tadpoles were exposed to fluoride concentrations either at 0, 1, 5, 10, or at 50 mg L(-1) from Gosner stage 26 to Gosner stage 42. Body weight,
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Measurement and analysis of several examination indices of endemic fluorosis sufferers
Objective: Explore the measurement of diagnosis indices significant for endemic fluorosis. Method: 600 patients with minor, medium, and severe degrees of fluorosis were selected, and 21 examinations were performed on their blood, urine, and biochemistry. Ion-selective electrodes were used for blood and urine fluoride, and RABA biochemical automatic analyzers were
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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