Excerpt:

The familial pituitary or central diabetes insipidus (DI) is a relatively rare condition with variable onset, from birth to several years of age and variable severity within a family and in individuals over time(l). Severe dehydration and growth retardation, though rare are known compilations of DI. However, dental fluorosis as a complication of DI has been described in the literature only in three families(2,3). Further, severe crippling deformities due to skeletal fluorosis has not been reported in the literature to the best of our knowledge. We report two brothers with central diabetes insipidus who developed severe skeletal and dental fluorosis from early childhood.

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