Abstract
Ingestion of sodium fluoride at 100 and 300 ppm in drinking water for 12 weeks by adult male Sprague-Dawley rats was investigated for effects on territorial aggression, sexual behavior, and fertility. Body weight and absolute and relative testes weights were not affected, but the average weights of epididymis, ventral prostate, seminal vesicles, and preputial glands decreased significantly. A significant decline of spermatogenesis in testes due to a decrease in the number of spermatocytes (primary and secondary) and spermatids in the treatment group is attributed to a significant decrease in testosterone. Sperm motility and density were also significantly decreased in the cauda epididymis and in testes in both NaF- treated groups. In addition, the treatment markedly diminished aggressive and sexual behavioral parameters such as lateralization, boxing bouts, and ventral presenting postures. It also prolonged the time to the first mount, increased the intromission latency, decreased the number of intromissions, prolonged the post- ejaculatory interval, and increased the number of fetal resorptions in female rats impregnated by these males, thereby reducing their fertility.
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Perinatal exposure to sodium fluoride with emphasis on territorial aggression, sexual behaviour and fertility in male rats.
Territorial aggression, sexual behaviour and fertility parameters were evaluated at adulthood of male rats previously exposed to different concentrations of sodium fluoride (Na-F) at their gestation, lactation and postweaning period till maturation. Sixty weanling male Wistar rats were received Na-F via their dams from second trimester of their pregnancy onward
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Testing the potential of sodium fluoride to affect spermatogenesis in the rat
The potential of sodium fluoride (NaF) to affect spermatogenesis and endocrine function was assessed in P and F1 generation male rats. Male and female experimental rats received sodium fluoride in their drinking water at one of four concentrations (25, 100, 175, 250 ppm). P generation male and female rats were
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Suppression of male reproduction in rats after exposure to sodium fluoride during early stages of development
Sodium fluoride (NaF), a widespread natural pollutant was given to sperm-positive female rats throughout gestation and lactation at a dose of 4.5 and 9.0 ppm via drinking water. The neonates were allowed to grow up to 90 days on tap water, and then sperm parameters, testicular steroidogenic marker enzyme activity
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Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea pigs' testis
Highlights F and Al changed histological structure of testes, reduced sperm quality. F and Al reduced StAR and P450scc expressions and level of serum testosterone. F toxicity is stronger than Al and Al weakened the toxicity of F. Al had antagonism effects on F. A lot of studies have shown
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NaF may disturb male fertility in rodents
An increase in the potential for lipoperoxidation in the rat testis and a decrease in rodents fertility by NaF has been reported (Pinto et al., 1997, Pharm. Toxicol., 80, III, 117; Chinoy et al., 1992, J. Environ. Biol 13, 55). However, other authors described that spermatogenesis in the rat is
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NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
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