Abstract
The effect of fluoride on testicular lipid metabolism was assessed in male albino rabbits in experimental fluorosis. Fifty male albino rabbits were administered sodium fluoride (5, 10, 20, and 50 mg/kg body weight/day) subcutaneously for 100 days. The control animals were given 1 cc distilled water/kg body weight over the same period. Compared with controls, the experimental animals especially those given 50 mg NaF/day/kg of body weight, showed abnormal accumulation of lipids in testes. Hyperphospholipidemia, hypertriglyceridemia, and hypercholesterolemia in tesces indicate enhanced lipid biosynthesis in response to fluoride toxicosis. A progressive significant (p < 0.001) increase in amount of free fatry a.cids was observed in testes of fluoridated animals. The increase of concentration of all lipid classes except free falty acids in testes was directly correlated with the increase in dosage of fluoride administered.
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Effects of sodium fluoride and sulfur dioxide on oxidative stress and antioxidant defenses in rat testes
To assess effects of sodium fluoride and sulfur dioxide on oxidative stress and antioxidant defenses in the testes, 96 sexually mature male Wistar rats were divided randomly into four groups of twenty-four rats each. One group of rats was left untreated as controls, and the other three groups were administered,
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Evaluation of the toxicity of fluorine in Antarctic krill on soft tissues of Wistar rats
Antarctic krill are a potential food source for humans and animals, but krill are known to contain high levels of fluorine (F). In this study, we investigated the toxicity of F in Antarctic krill using Wistar rats. There were three experimental groups: The control group were fed a basal diet,
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Toxic effects of sodium fluoride on reproductive function in male mice
To investigate the effects and possible mechanisms of the action of fluoride on testis cell cycle and cell apoptosis in male mice, sexually mature male Kunming mice were exposed to 50, 100, 200, and 300 mg NaF/L in their drinking water for 8 weeks. At the end of the exposure
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Effects of Fluoride on SOD and CAT in Testis and Epididymis of Mice.
Oxidative damage has been implicated to be one of main mechanisms by which fluoride (F) induces toxic effects. Previous studies reported that F destroyed the epididymal structure of mouse and rabbit. Epididymis is the important place for sperm maturation. However, little is known about the effect of F on the
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Effects of sodium fluoride and sulfur dioxide on sperm motility and serum testosterone in male rats
Ninety-six sexually mature male Wistar rats were divided randomly into four groups of twenty-four rats. In experiments to assess effects of sodium fluoride and sulfur dioxide on their sperm motility and serum testosterone (T), one group of rats was left untreated as controls, and the other three groups were administered,
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of overĀ 60 animal studiesĀ from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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