Abstract

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  • The influence of fluoride on the content of testosterone and cholesterol in rat

    Fifty four Wistar male rats were randomly divided into three groups, drinking water containing 0.6 mg/L (control group), 100 mg/L, and 200 mg/L sodium fluoride, respectively. Rats were killed at the second, fourth and sixth weeks after experiment initiation, respectively. The levels of serum testosterone, testis cholesterol, and hepatic tissue

  • [Excessive fluoride increases the expression of osteocalcin in the mouse testis].

    OBJECTIVE: To observe the influence of excessive fluoride on the levels of osteocalcin and testosterone in the testis of the male mouse. METHODS: Twenty-four C57BL/6J male mice were equally randomized into a normal control and a fluorosis model group, the former fed on distilled water while the latter on a solution of sodium

  • Toxic effects of sodium fluoride on reproductive function in male mice

    To investigate the effects and possible mechanisms of the action of fluoride on testis cell cycle and cell apoptosis in male mice, sexually mature male Kunming mice were exposed to 50, 100, 200, and 300 mg NaF/L in their drinking water for 8 weeks. At the end of the exposure

  • Ultrastructural studies on the leydig cells of rabbits exposed to chronic fluoride toxicity

    The present communication addresses the effect of chronic fluoride toxicity on the structure of rabbit Leydig cells using light, scanning and transmission electron microscopy. An ion-specific electrode method was used for the determination of fluoride in sera. The levels of fluoride in the sera of fluoride exposed rabbits were significantly

  • Reproductive toxicity of fluoride

    Perfluorochemicals are compounds in which all the hydrogen atoms have been replaced by fluorine atoms. Because of their high capacity to dissolve oxygen, perfluorochemicals have been used as artificial oxygen carriers in organ perfusions. Previous experiments suggested that perfluorochemicals failed to support testosterone secretion by rat testes. We hypothesized that

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  • Fluoride's Effect on the Male Reproductive System -- In Vitro Studies

    Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.

  • Fluoride's Effect on Male Reproductive System: Animal Studies

    Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.

  • Fluoride's Effect on Male Reproductive System - Human Studies

    Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.

  • Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly

    In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study