Pharmacokinetic aspects of topical fluorides

Pharmacokinetic studies have revealed quantitative information about the bioavailability, rate of absorption, distribution, and clearance of fluoride following the use of fluoride-containing dentifrices, gels, varnishes, and solutions. It is concluded that following the use of topical fluoride products, variable amounts of fluoride are swallowed and absorbed into the systemic circulation--amounts which may be sufficient to produce acute

Changes of acute harmful effects and fluoride kinetics after single intravenous injection of sub-toxic hydrofluoric acid in rats-Renal dysfunction, abnormal serum electrolytes, metabolic acidosis and fluoride kinetics.

Hydrofluoric acid (HFA) is used widely in many industrial processes. There have been many reports on the acute lethal effects of HFA in relation to occupational accidents. This study was designed to investigate the time-dependent harmful effects after exposure of sub-toxic doses. The serum fluoride ion (F) kinetics is also

Changes in the metabolism of glucose and calcium following a single large dose of fluoride to rats

Serum glucose level was elevated immediately after ip administration of a single large dose of fluoride (NaF 35 mg/kg) to rats. The elevation of serum glucose was markedly suppressed by adrenalectomy, dibenamine or propranolol, but not by thyroid-parathyroidectomy. Elevation of serum glucose was found to be associated with enhancement of

Chronic toxicity of dietary sodium monofluorophosphate in growing rats, with special reference to kidney changes

Study of children drinking fluoridated and nonfluoridated water

A special study was made of the quantitative excretion of albumin, red blood cells, and casts in 12-hour urine specimens in 12-year-old boys as part of the long-term study of children in the Newburgh-Kingston caries fluorine study. The objective of this study was to determine whether any irritative efIects on

Fluoride as a Cause of Kidney Disease in Animals

Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing in

Fluoride Gels & Kidney Function

Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each

Fluoride & Kidney Stones

It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium

Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence

A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.

Fluoride as a Cause of Kidney Disease in Humans

Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing