Abstract
Objective: To probe into the changing regularity of sclerotic skeletal fluorosis after patients changed to drink low-fluorine water for the long term. Methods: Study subjects were patients with sclerotic skeletal fluorosis who changed to drink low-fluorine water 16–25 years ago, and their sclerotic skeletal fluorosis had been proven by bone X-ray at the beginning of or prior to this change; their anteroposterior X-ray films of the pelvis, right forearm and right lower limb were taken for comparison and analysis. Results: The bone substances of all subjects improved remarkably after they changed to drink low-fluorine water for the long term, and 21.47% of them resumed a normal state. The morphology of bone trabecula was not improved for 18.75%–85.75% of cases, and dense bone trabecula became osteoporotic for most cases. The ossification of peri-osseous soft tissues worsened for 73.33% of cases and the degenerative changes of bone joints worsened for 80%. Conclusion: The bone substances of sclerotic skeletal fluorosis can improve remarkably after patients change to drink low-fluorine water for the long term, and so a portion of patients may resume the normal state. Two consequential effects of sclerotic skeletal fluorosis are osteoporosis and exacerbation of ossification of peri-osseous soft tissues.
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Industrial Fluorosis [Carnow et al.]
SUMMARY: In 1242 apparently healthy and actively employed workers of a Canadian aluminum facility, the history of musculoskeletal symptoms, of the incidence of fractures, of neck and back surgery, as well as the x-ray findings were reviewed. A highly significant relationship of exposure to fluoride was established with the frequency
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Fluorosis in Aden
The cases to be described here occurred in the Aden Protectorate where for the last 12 years mass screening of the chest to exclude pulmonary tuberculosis has been carried out. The patients had all drunk the brackish water from the wells, and the analysis of the water from a well
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Endemic fluorosis in the Madras presidency
1. Ten cases of chronic fluorine intoxication have been investigated, clinically, radiologically, and, as regards blood and urine, biochemically. 2. The clinical picture is described and relates chiefly to disabilities caused by calcification of ligaments, tendons and fasciae, the formation of osteophytic outgrowths of bone and the nervous effects of mechanical
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Multiple painless masses: periostitis deformans secondary to fluoride intoxication
Diagnosis The differential diagnosis based on the imaging findings included ossification of subperiosteal hematomas, ectopic calcification in the setting of a connective tissue disorder, and periostitis deformans secondary to fluoride intoxication. Laboratory assays were requested by the patient’s rheumatologist, which were notable for a mildly elevated alkaline phosphatase level (216 U/L,
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Skeletal fluorosis. A report of two cases
Two illustrative cases of patients with skeletal fluorosis and classic radiographic changes are presented. One patient demonstrated a progressive paraparesis, while the other was diagnosed incidentally on routine radiographs. A review of the literature, treatment, and histologic findings are presented.
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"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
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Skeletal Changes in Industrial and Endemic Fluorosis
Fluorotic changes in bones and joints were evaluated in 105 aluminum workers and 20 residents of an endemic fluorosis region in India.
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Symposium on the non-skeletal phase of chronic fluorosis: The Joints
Of 300 patients with endemic skeletal fluorosis 187 (110 children and 77 adults) showed evidence of arthritis. The spine, especially its cervical portion, appeared to be mainly involved; elbow, hip and knee joints followed next in order.
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