Abstract
Objective: To probe into the changing regularity of sclerotic skeletal fluorosis after patients changed to drink low-fluorine water for the long term. Methods: Study subjects were patients with sclerotic skeletal fluorosis who changed to drink low-fluorine water 16–25 years ago, and their sclerotic skeletal fluorosis had been proven by bone X-ray at the beginning of or prior to this change; their anteroposterior X-ray films of the pelvis, right forearm and right lower limb were taken for comparison and analysis. Results: The bone substances of all subjects improved remarkably after they changed to drink low-fluorine water for the long term, and 21.47% of them resumed a normal state. The morphology of bone trabecula was not improved for 18.75%–85.75% of cases, and dense bone trabecula became osteoporotic for most cases. The ossification of peri-osseous soft tissues worsened for 73.33% of cases and the degenerative changes of bone joints worsened for 80%. Conclusion: The bone substances of sclerotic skeletal fluorosis can improve remarkably after patients change to drink low-fluorine water for the long term, and so a portion of patients may resume the normal state. Two consequential effects of sclerotic skeletal fluorosis are osteoporosis and exacerbation of ossification of peri-osseous soft tissues.
-
-
Comparison of two village primary schools in northern Tanzania affected by fluorosis
High fluoride levels in drinking water sources are a problem throughout the East African Rift Valley and can lead to dental fluorosis (DF) and skeletal fluorosis (SF) in exposed local populations. Two villages in the Hai District of northern Tanzania in which fluoride has been identified as a problem were
-
[Bone fluorosis without occupational exposure in chronic renal insufficiency].
Report on a 70-year-old male with bone fluorosis which was ascertained radiologically, by section and fluor analysis in the bone ash. With empty professional anamnesis as cause was found the presence of a chronic renal insufficiency with simultaneously increased fluor content of drinking water. The decreased renal excretion of fluoride
-
Recovery from skeletal fluorosis
Kurland et al.(1) reported a fascinating case of skeletal fluorosis in a man who probably ingested significant quantities of fluoride from toothpaste. They report that after withdrawal of fluoride, there was a short initial period of rapid bone loss, followed by a prolonged period of slow BMD loss from the
-
Effect of sodium fluoride on collagen cross-link precursors.
Rabbits of similar age and body weight received sodium fluoride (NaF) (50 mg/kg body weight/day) intragastrically for up to 136 days. The acid-soluble collagen of bone, tendon, trachea and skin was extracted and purified. Aldehyde associated with the collagen was determined spectrophotometrically. Bone collagen, which had maximum aldehyde content in
-
Fluorosis in horses drinking artifically fluoridated water
Quarter Horses drinking water artificially fluoridated at 0.9 to 1.1 ppm over long periods of time developed dental fluorosis. Even when the horses had not been exposed to artificially fluoridated water (AFW) during formation of enamel, brown discoloration occurred and progressed. Pronounced loss of tooth-supporting alveolar bone with recession of
Related Studies :
-
-
-
Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
-
"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
-
Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
-
Fluoride & Osteopetrosis
One of the most common radiological findings in skeletal fluorosis is osteosclerosis - a hardening of bones with a blurring of the trabecular structure. In advanced cases, the osteosclerotic form of fluorosis may closely resemble the appearance of osteopetrosis, a "marble bone" disease in which the bones are dense, but fragile and prone to fracture.
-
Fluoridation, Dialysis & Osteomalacia
In the 1960s and 1970s, doctors discovered that patients receiving kidney dialysis were accumulating very high levels of fluoride in their bones and blood, and that this exposure was associated with severe forms of osteomalacia, a bone-softening disease that leads to weak bones and often excruciating bone pain. Based on
Related FAN Content :
-