Abstract

Objective To study the effect of high level fluoride and low level iodine on learning-memory in offspring rats and possible mechanism.

Methods Thirty-two Wistar rats were randomly divided into four groups each of eight (female:male=(3:1).) The rats were treated with high fluoride (100 and 150 mg NaF/L), low iodine (0.0855 mg/kg), or both high fluoride (100 and 150 mg NaF/L) and low iodine (0.0855 mg/kg) respectively.

Results Compared with control rats,error number (EN1) and (EN2) of the experimental offspring rats increased significantly (P0.05). Sustaining time (ST) reduced obviously (P0.05). EN1 and EN2 of the experimental rats in the group of high fluoride and low iodine were the highest in all groups (P0.05). Acetylcholinesterase (TchE) activity in the group of high fluoride and low iodine decreased significantly at 30,60 and 90 days (P0.01).

Conclusion TchE activity of brain by high fluoride and low iodine may be an important mechanism to affect learning-memory ability.

• Related Studies :

  • Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats

    Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both

  • A correlation between serum vitamin, acetylcholinesterase activity and IQ in children with excessive endemic fluoride exposure in Rajasthan, India

    Fluoride  is  widely  distributed  in  nature  and  a  direct  source  of  adverse  health  effects  in  human  populations.  Fluoride poisoning  attributed  by  long-term  exposure  to  high  levels  of  fluoride  [is] called  fluorosis.  The  present  study was  carried  out among  9-14  years  old  school  children  of Dausa  district,  Rajasthan  India.  The  subjects

  • Proteomic analysis of brain proteins of rats exposed to high fluoride and low iodine.

    Epidemiological investigations reveal that high fluoride and low iodine have strong adverse effects on the intelligence quotient (IQ) of children. Studies also report that in some high fluoride areas, iodine deficiency also exists, especially in China. Here, with the proteomic techniques, we first report on the proteomic changes in brain

  • Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride-induced adverse changes in acetylcholinesterase activity in rats

    The objective of this study was to determine the effect of fluoride (F) and arsenic (As) on the activity of acetylcholinesterase (AChE), a critically important nervous system enzyme, and to test the protective role of buffalo epiphyseal (pineal) proteins (BEP) in rats. Arsenic (20 mg/kg BW, intraperitoneally) and F (150

  • Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats

    Spontaneous motor activity, rota-rod performance (motor co-ordination), body weight gain, food intake, activities of total cholinesterase (blood) and acetylcholinesterase (brain), and dental structure were determined in adult female rats treated with a very high dose of sodium fluoride (500 ppm in drinking water) alone and in combination with calcium carbonate

• Related FAN Content :

  • Nutrient Deficiencies Enhance Fluoride Toxicity

    It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,

  • Kidney Patients Are at Increased Risk of Fluoride Poisoning

    It is well established that individuals with kidney disease are susceptible to suffering bone damage and other ill effects from low levels of fluoride exposure. Kidney patients are at elevated risk because when kidneys are damaged they are unable to efficiently excrete fluoride from the body. As a result, kidney patients

  • Fluoride Is Not an Essential Nutrient

    In the 1950s, dentists believed that fluoride was a “nutrient.” A nutrient is a vitamin or mineral that is necessary for good health. Dentists believed that fluoride ingestion during childhood was necessary for strong, healthy teeth. A “fluoride deficiency” was thus believed to cause cavities, just like a deficiency of calcium can

  • Factors which increase the risk for skeletal fluorosis

    The risk for developing skeletal fluorosis, and the course the disease will take, is not solely dependent on the dose of fluoride ingested. Indeed, people exposed to similar doses of fluoride may experience markedly different effects. While the wide range in individual response to fluoride is not yet fully understood, the following are some of the factors that are believed to play a role.

  • Fluoride, Water Hardness, and Endemic Goitre

    Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.