Abstract

Analytic chemical studies of similar human skeletal tissues obtained at autopsy from two comparable women were conducted to determine the effect of a prolonged exposure to drinking water containing 8.0 ppm of fluoride on the chemistry of human bones.

As a result of the prolonged .use of this fluoride drinking water, the fluoride in dry, fat-free skeletal tissues ranged from 0.512 to 0.653 percent, as compared with 0.062 to 0.092 percent fluoride in the skeletal tissues of a subject, comparable in age, height, weight, and sex, with no unusual water-fluoride exposure.

There was some indication that the prolonged use of drinking water containing 8.0 ppm fluoride accounted for an increase in the ash and a slight increase in the calcium content of the skeletal tissues.

The absence of any gross of systemic findings, or of any impairment of the skeletal tissues, or malfunction generally in the one subject studied, indicates that human bone may not be affected by as much as 0.5 to 0.6 percent fluoride. These findings compare favorably with other previous evidence pertinent to human bone as well as fluorosed animal bones.

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