Abstract

The Assam region of NE India has been recognized only recently as a fluoride-affected area. Surveys indicate that one-seventh of the 700,000 people in the Karbianglong district of Assam have either dental or skeletal fluorosis. The high concentration of fluoride in the water resources in some localities such as the Ramsapathar (>20.6 mg/L) and Lungnit (>15.4 mg/L) areas of the district are of great concern. In this report we present available information concerning the waterborne fluoride scenario of Karbianglong.

• Related Studies :

  • An epidemiological, clinical and biochemical study of endemic, dental and skeletal fluorosis in Punjab

    Since 1958 the Department of Medicine, Patiala, has been actively engaged in epidemiological, clinical amd biochemical studies of endemic fluorosis in Punjab, one of the most highly endemic areas in the world. Extensive data on dental, skeletal and neurological aspects of fluorosis have been fully reported in our earlier studles

  • [Hazards of development of occupational fluorosis in manufacture of phosphorus-containing mineral products].

    Complex studies pertaining to the production of phosphorus-containing mineral products detected no cases of occupational fluorosis among workers. The reasons for fluorosis absence in fluorine-exposed workers were analyzed. The total fluorine load was calculated in workers of the main professions. It was demonstrated that fluorine annual intake of 2-4 g

  • The effects of excessive fluoride intake

    A survey undertaken in areas of Tanzania where the water has a very high fluoride content showed mottling of the teeth. Some skeletal fluorotic changes were found in some older people. The problem of reducing the fluoride content of the water to acceptable levels is discussed.

  • Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.

    Highlights Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification. Abstract Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway

  • Multicentric hyperostosis consistent with fluorosis in captive fruit bats (Pteropus giganteus, P. poliocephalus, and Rousettus aegyptiacus)

    Nodular bone lesions were identified in three species of fruit bat in the Metropolitan Toronto Zoo collection: 25 of 43 Indian fruit bats (Pteropus giganteus), eight of eight grey-headed flying foxes (P. poliocephalus), and seven of 45 Egyptian fruit bats (Rousettus aegyptiacus). The condition was investigated by retrospective study of

• Related FAN Content :

  • "Pre-Skeletal" Fluorosis

    As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.

  • Skeletal Fluorosis: The Misdiagnosis Problem

    It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.

  • Fluoride & Osteoarthritis

    While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.

  • Factors which increase the risk for skeletal fluorosis

    The risk for developing skeletal fluorosis, and the course the disease will take, is not solely dependent on the dose of fluoride ingested. Indeed, people exposed to similar doses of fluoride may experience markedly different effects. While the wide range in individual response to fluoride is not yet fully understood, the following are some of the factors that are believed to play a role.

  • Mayo Clinic: Fluoridation & Bone Disease in Renal Patients

    The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.