Abstract

The effects of tidal volume and respiratory frequency on the deposition of NaF aerosol particles were studied using lungs isolated from 20 rabbits. Total lung deposition decreased with increases in tidal volume and respiratory flow rate and was in the range of 20-80% when the reciprocal of the respiratory flow rate was 0.05-0.5 sec/ml. Deposition of aerosol particles in various lung lobes had a 1:1 ratio with respect to the weight of each lobe. The deposition was especially high on the right middle lobe and markedly decreased with increases in respiratory flow rate.