Abstract
The study comprised 46 children (25 boys and 21 girls) aged 10 to 14 years with endemic mottled enamel. From birth all children used aqueductal potable water containing supraoptimal amount of fluorine equal to 2,68 mg/ml. The control group consisted of 40 children from Lód? children care homes free from mottled enamel in whom endogenic fluoridation has been performed using Fluodar tablets according to generally accepted instructions. In both groups of children the fluorine content in the blood serum and urine has been determined. The children with mottled enamel the fluorine excretion with urine was statistically significantly higher than in the control group. Moreover, the children with mottled enamel showed higher concentration of fluorine in the urine than in the serum whereas in the control group the fluorine concentration in the urine and in the serum were almost identical.
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Dose-dependent effect of fluoride on clinical and subclinical indices of fluorosis in school going children and its mitigation by supply of safe drinking water for 5 years: An Indian study.
Fluorosis is a public health problem in India; to know its prevalence and severity along with its mitigation measures is very important. The present study has been undertaken with the aim to assess the F dose-dependent clinical and subclinical symptoms of fluorosis and reversal of the disease by providing safe
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The Conclusion of a Ten-Year Study of Water Fluoridation.
Note: The Tables are not included in the text below. See the full study. In areas where the potable water supplies contain the fluoride ion at optimum concentration at the source, the dental caries experience of children who ingest these water fluorides during the years of tooth development is about 60
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Biomarkers for the Assessment of Fluoride Exposure in Children.
Due to practical difficulties in quantifying fluoride exposure, the ability of various biomarkers to predict exposure has been investigated previously. However, the results are inadequate for validation of their application and usefulness. This study aimed to investigate the association between contemporary/recent biomarkers of fluoride exposure and total daily fluoride intake
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Fluoride Metabolism in Pregnant Women: A Narrative Review of the Literature.
(This article belongs to the Special Issue Fluoride Metabolism and the Effects of Fluoride on Metabolic Pathways and Diseases) Abstract Epidemiological studies use biomarkers of fluoride exposure in pregnant women as surrogate measures of fetal fluoride exposure; however, there is little understanding of how pregnancy affects fluoride metabolism and its biomarkers. This
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Excess fluoride ingestion and thyroid hormone derangements in children living in Delhi, India
SUMMARY: Ninety children with dental fluorosis, aged 7–18, living in fluoride endemic, non-iodine deficient areas of the National Capital Territory of Delhi, India, where iodized salt has been promoted for over a decade, were investigated, along with 21 children in two control groups without dental fluorosis living in non- endemic
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Another Fluoride Fatality: A Physician's Dilemma
Why do physicians fail to correctly evaluate the toxicity of fluoride? Most textbooks rely on the now outdated views of Smith and Hodge who 25 years ago designated 5 to 10 g of fluoride the fatal toxic dose.
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Dental Fluorosis: The "Cosmetic" Factor
Any condition that can cause children to be embarrassed about their physical appearance can have significant consequences on their self-esteem and confidence. Researchers have repeatedly found that "physical appearance [is] the best predictor of self-esteem" in adolescents, (Harter 2000) and that facial attractiveness, particularly the appearance of one's teeth, is a
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Severe Dental Fluorosis: Perception and Psychological Impact
[caption id="attachment_8879" align="aligncenter" width="550"] Severe fluorosis - Photograph by David Kennedy, DDS[/caption] In its severe forms, dental fluorosis causes highly disfiguring brown and black staining of the teeth, which can cause chronic embarrassment and social anxiety for the impacted child. In 1984, a panel from the National Institute of Mental Health (NIMH) warned
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Dental Fluorosis Impacts Dentin in Addition to Enamel
Dental fluorosis is a mineralization defect of tooth enamel marked by increased subsurface porosity. The enamel, however, is not the only component of teeth that is effected. As several studies have demonstrated, dental fluorosis can also impair the mineralization of dentin as well. As noted in one review: "The fact that
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Dental Fluorosis Is a "Hypo-mineralization" of Enamel
Teeth with fluorosis have an increase in porosity in the subsurface enamel ("hypomineralization"). The increased porosity of enamel found in fluorosis is a result of a fluoride-induced impairment in the clearance of proteins (amelogenins) from the developing teeth. Despite over 50 years of research, the exact mechanism by which fluoride impairs amelogin
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