Abstract
BACKGROUND: The purpose of this study was to determine the concentration of inorganic arsenic (As) in the potable water available to the population to be able to estimate the non-carcinogenic risks for underweight children and the carcinogenic risk for adults exposed to As intake who live in the Mezquital municipality, Durango, Mexico.
METHODS: The As content was quantifed in the water supply sources for human use and its intake was estimated in Mezquital population, southern Durango. With the data obtained, the hazard quotient (HQ) was calculated to determine the non-carcinogenic risk to develop chronic systemic effects in underweight children. The Environmental Protection Agency (EPA) reference health values estimating As exposure risk are from 0.0003 mg/kg/day (non-carcinogenic) to 1.5 mg/kg/day (carcinogenic risk).
RESULTS: The analyzed waters presented as concentrations that varied from 0.3 to 10.2 µg/L, with a mean of 7.35 µg/L (CI 95% 6.27-8.38). The exposure dose was 0.4 to 1.36, and the HQ was 1.90 to 6.48 mg/kg/day, the estimated carcinogenic risk from adults varied from 1.28 to 4.37E-4, with values of 3.74-4.37E-4 mg/kg/day in central area.
CONCLUSIONS: The children are at risk to develop chronic systemic effects due to ingestion of As from water.
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[A clinical study on the syndrome of arsenism and fluorosis].
A clinical study was made on 65 cases with the syndrome of arsenism and fluorosis (SAD) from March 1982 to August 1989. All the cases with this syndrome had drunk a well water containing arsenic 0.6 mg/L and fluorine 3.45 mg/L for a long period. The patients all had the
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Subchronic exposure to arsenite and fluoride from gestation to puberty induces oxidative stress and disrupts ultrastructure in the kidneys of rat offspring.
Highlights In utero and early life exposure to As and F affects kidney ultrastructure. Exposure to As and F alone or combined causes oxidative stress in kidney tissue. As exposure but not F alters the Nrf2 pathway-related signaling molecules. Concurrent As and F exposure may produce a joint action on
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Scenario, Perspectives and Mechanism of Arsenic and Fluoride Co-occurrence in the Groundwater: A Review.
Highlights: First review on co-occurrence perspectives of Arsenic and Fluoride in the groundwater. As and F co-occurrences is quite common yet concealed owing to one being dominant. Arid areas are more suitable for co-occurrence with few reports in the Alluvium plains. Local hydro-geochemical processes and seasonality greatly affect co-contamination. Co-contamination
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Effect of arsenic and/or fluoride gestational exposure on renal autophagy in offspring mice.
Highlights The exposure of fluoride and arsenic in the mother rats induced the autophagy in the kidney of the offspring mice. Under the experimental conditions, the combination of As and F showed certain antagonistic effects. The expression of autophagy negative regulator p62 is increased, which may be due to autophagic
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Probabilistic human health risk assessment associated with fluoride and arsenic co-occurrence in drinking water from the metropolitan area of San Luis Potosí, Mexico.
A major public health concern in Mexico is the natural contamination of groundwater with fluoride and arsenic. Therefore, this work aimed to evaluate the magnitude of human health risk after determining fluoride and arsenic concentrations in groundwater samples (n = 50) from the Metropolitan area of the city of San
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Nutrient Deficiencies Enhance Fluoride Toxicity
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