Abstract
To explore the threshold effect of body mass index (BMI) on bone mineral density (BMD) in Chinese women living in the fluorosis area, we conducted a cross-sectional study and recruited 722 women in rural areas in Henan Province, China. After detection and analyses, we found that compared with the normal BMI group, the risk of osteoporosis in the overweight and obese groups were reduced by 32% and 69%, respectively. Threshold effect analysis showed that BMD was positively correlated with BMI when BMI was 16.8-31.2 kg/m2; while when BMI was greater than 31.2 kg/m2, the correlation reached saturation. The correlation observed between low-to-moderate fluoride exposure and BMD in rural women was not significant.
Keywords: Body mass index; Bone density; Fluoride; Osteoporosis.
*Original abstract online at https://pubmed.ncbi.nlm.nih.gov/33147932/
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Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study.
OBJECTIVE: To investigate the associations between period-specific and cumulative fluoride (F) intakes from birth to age 17 years, and radial and tibial bone measures obtained using peripheral quantitative computed tomography (pQCT). METHODS: Participants (n = 380) were recruited from hospitals at birth and continued their participation in the ongoing Iowa Fluoride Study/Iowa Bone Development
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Fluoride reduces bone strength in older rats
In response to recent concerns about the effect of water fluoridation on hip fracture rates, we studied the influence of fluoride intake on bone strength. Four groups of rats were fed a low-fluoride diet ad libitum and received 0, 5, 15, or 50 ppm of fluoride in their drinking water.
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Fluoride exposure and bone status in patients with chronic intestinal failure who are receiving home parenteral nutrition
BACKGROUND AND OBJECTIVE: Metabolic bone disease is frequent in chronic intestinal failure. Because fluoride has a major effect on bones, the status of both fluoride and bone was studied in long-term home parenteral nutrition (HPN) patients. DESIGN: We studied 31 adults aged (x +/- SD) 56.3 +/- 15.1 y, mainly
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Fluoride exposure and CALCA methylation is associated with the bone mineral density of Chinese women.
Highlights Excessive fluoride exposure is positively related to CALCA methylation in women. CALCA methylation in Chinese women is negatively associated with BMD. Long-term excessive fluoride exposure is negatively related to BMD in women. BMD in women with CALCA hypermethylated is more susceptible to fluoride. The statistical associations are age-specific
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Association between low-to-moderate fluoride exposure and bone mineral density in Chinese adults: Non-negligible role of RUNX2 promoter methylation.
Highlights RUNX2 promotor methylation is positively related to excessive fluoride (F) exposure. Bone mineral density (BMD) is negatively related to excessive F exposure in women. BMD is negatively associated with RUNX2 promotor methylation in women. RUNX2 methylation mediates the association of excessive F exposure and BMD in women. Bone mineral density
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