Abstract

Fluorosis is a metabolic disease that is endemic in nearly 25 countries with India being one of the most affected. It primarily affects the bone and the teeth. Moringa oleifera (MO) leaves are known to reduce the effect of fluorosis on various tissues. Therefore, it is of interest to document the effect of Moringa oleifera leaves on the hematological profile of fluorosis affected rats. Twenty four Sprague Dawley rats were housed two per cage in a room with 12 hours light and 12 hours dark cycle. The rats were allowed to adjust to the laboratory environment for about one to two weeks before the beginning of the study. This study reveals that MO leaves is effective in reducing the plasma fluoride content. It also helps in improving the Hb % and RBC count in fluorosis affected rats. Data shows that Moringa olifera leaves powder is effective in reducing the plasma fluoride content. It also helps in improving the Hemoglobin percentage & Red Blood Cell count in fluorosis affected rats.

*Original full-text article online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200611/

Excerpt:

References:

1. Mandal KD, et al. Vet World . 2015;8:1364. [PMC free article] [PubMed] [Google Scholar]

2. Madhuri SK. Indian J Anaesth . 2016;60:157. [PMC free article] [PubMed] [Google Scholar]

3. Warren JJ, et al. Public Health Dent . 2009;69:111. [PMC free article] [PubMed] [Google Scholar]

4. Shivashankara AR, et al. Fluoride . 2000;33:66. [Google Scholar] https://www.fluorideresearch.org/

5. Patra RC, et al. Sci Total Environ . 2000;253:145. [PubMed] [Google Scholar]

6. Gupta AR, et al. Vet Arc . 2013;83:487. [Google Scholar]

7. Maryam A, et al. Toxicol Rep . 2017;4:450. [PMC free article] [PubMed] [Google Scholar]

8. Susheela A. Fluoride . 2001;34:181. [Google Scholar] https://www.fluorideresearch.org/

9. Susheela AK, Toteja GS. Indian Journal of Medical Research . 2018;148:539. [PMC free article] [PubMed] [Google Scholar]

10. Jorfi S, et al. Iran J Health Environ . 2011;4:35. [Google Scholar] http://ijhe.tums.ac.ir/article-1-84-en.html .

11. Zazouli MA, et al. J Mazand Univ Med Sci. 2014;23:208. [Google Scholar]

12. Sultana B, et al. Molecules . 2009;14:2167. [PMC free article] [PubMed] [Google Scholar]

13. Luqman S, et al. Evid Based Complement Alternat Med . 2012 [PMC free article] [PubMed] [Google Scholar]

14. Sanchez NR, et al. Agro for Syst . 2006;66:231. [Google Scholar]

15. Nouman W, et al. Turk J Agric . 2014;38:1. [Google Scholar]

16. Francis O, et al. Agricultura . 2016;13:71. [Google Scholar]

17. Stohs SJ, Hartman M. J. Phytother Res . 2015;29:796. [PMC free article] [PubMed] [Google Scholar]

18. Inkielewicz I, Krechniak J. Flouride . 2003;36:263. [Google Scholar]

19. Kumari S, Kumar A. Asian J Exp Biol Sci . 2011;2:283. [Google Scholar]

20. Ekambaram P, et al. Fluoride . 2010;43:134. [Google Scholar]

21. Shashi A, Sharma N. Int J of Basic and Applied Med Sci . 2015;5:146. [Google Scholar]

22. Anslem OA, et al. Int J Pub Health Safe . 2017;2:2. [Google Scholar]

23. Anwar F, et al. Phytother Res. . 2007;21:17. [PubMed] [Google Scholar]

24. Atsukwei D, et al. Int J Nutr Food Sci . 2014;3:355. [Google Scholar]

25. Vongsak B, et al. Ind Crops Prod . 2013;44:566. [Google Scholar]

26. Aja PM, et al. American J of Phyto Med and Clin Therapeutics. . 2014;2:2321. [Google Scholar]

27. Rawlani S, et al. Indian J Community Med. . 2010;35:298. [PMC free article] [PubMed] [Google Scholar]

28. Adegbite OA, et al. Ann Hematol Oncol. . 2016;3:1107. [Google Scholar]

29. Mangale SM, et al. Res J Recent Sci . 2012;1:31. [Google Scholar]

30. Anjorin TS, et al. Int J Agric Biol. 2010;12:431. [Google Scholar]

Print PDF

• Related Studies :

  • Chemical profile of blood in fluoride toxicity. III. Plasma fibrinogen levels in rabbit.

    Rabbits in two groups were given different doses of sodium fluoride i.e. low dose (10 mg NaF/kg body weight) and high dose (50 mg NaF/kg body weight). Blood was drawn from both groups on certain specific days after fluoride administration. The two different doses of sodium fluoride gave different response

  • Effect of inhaled waste anaesthetic gas on blood and liver parameters among hospital staff.

    A significant health risk exists within a section of health workers that are exposed to anaesthetic gas and vapours, found in the atmosphere of treatment or operating rooms. These compounds are classified as waste anaesthetic gases (WAG). The present study aimed at identifying alterations in hepatic and haematological parameters occurring

  • The association between fluoride in water and blood pressure in children and adolescents.

    Background The objective of this study was to determine the association between water and plasma fluoride and blood pressure (BP) among children and adolescents. Methods Our study population was individuals of 8–18 years in the 2013–2016 National Health and Nutrition Examination Survey. We performed a multivariable linear and logistic regression analysis to examine

  • Association between fluoride exposure and blood pressure in children and adolescents aged 6 to19 years in the United States: NHANES, 2013–2016.

    Highlights An inverse association was observed between water fluoride and childhood BP. Association between water fluoride and BP showed discrepancies in sex, age, arace. A negative association was found between plasma fluoride and BP only in other races. To examine the association between fluoride exposure and childhood blood pressure (BP), we

  • Fluoride concentrations in the human placenta and maternal and cord blood

    Fluoride concentrations in maternal and cord blood were measured for the first time with a method specific for inorganic fluoride. The concentrations averaged 0.88 ?M in blood from 16 mothers and 0.68 ?M in the cord blood, with a correlation of 0.86. These results are consistent with the hypothesis that