Tag: RNA

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Widespread genetic switches and toxicity resistance proteins for fluoride

July 2, 2021

Abstract Most riboswitches are metabolite-binding RNA structures located in bacterial messenger RNAs where they control gene expression. We have discovered a riboswitch class in many bacterial and archaeal species whose members are selectively triggered by fluoride but reject other small anions, including chloride. These fluoride riboswitches activate expression of genes that encode putative fluoride transporters, […]

Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.

November 16, 2019

Highlights Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification. Abstract Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride […]