Abstract
Eighty two children, aged 8 – 13 years old, from Wamiao village (severe endemic fluorosis area), from Xinhuai village (nonendemic fluorosis area) were 88 (as a control group), were recruited in this study. The prevalence of dental fluorosis (DF) were 85.37% (Wamiao) and 6.82% (Xinhuai) in two village’s children respectively; drinking water fluoride (F-) in children’s household shallow well from 0.62 – 4.00 mg/L in Wamiao and 0.23 – 0.76 mg/L in Xinhuai; serum total triiodothyronine (TT3), total thyronine (TT4), thyroid-stimulating hormone (TSH) were 1.47 ± 0.28 and 1.47 ± 0.33 ng/mL, 9.67 ± 1.76 and 9.22 ± 2.54 mg/dL, 3.88 ± 2.15 and 2.54 ± 2.07 mIU/mL in two villages children respectively. The prevalence of DF, drinking water F-, serum TSH in Wamiao village was significantly higher than that in Xinhuai village. As the children in Wamiao village were divided into different subgroups according to their severity of DF, serum TT3 and TSH showed significant difference in different groups. The results in this study confirmed that the high F- exposure can caused functional abnormalities of thyroid, and the different severity degree of DF may be relation to significant deviation in the serum levels of thyroid hormone.
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[Joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin].
Objective To investigate the joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin. Methods According to the concentration of fluoride and iodine in drinking water,four small towns in two counties of Tianjin were classified into three groups of high fluoride and iodine,high fluride,and control.Children aged 8-10 years in
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Effect of long-term fluoride administration on thyroid hormones level blood in rats
The effect of 2 months fluoride administration (0.1 and 1.0 mg daily/rat) on thyroxine and triiodothyronine level in blood and T3-resin uptake ratio was investigated in rats. In addition, free thyroxine index was calculated from serum thyroxine level and T3-resin uptake ratio. It was found that fluoride administration caused: 1.
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Study on serum T4, T3 and TSH levels in patients with chronic skeletal fluorosis
A study on the serum T4, T3, and TSH levels was performed in 27 patients with chronic skeletal fluorosis and the data obtained were compared with those of 20 healthy persons. The results showed that serum T4 in the patients was lower than in the controls and TSH was higher.
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Chronic effects of fluoride on growth, blood chemistry and thyroid hormones in adolescents residing in three communities in Northern Mexico
This study was designed to evaluate adverse health effects in adolescents from chronic exposure to various water fluoride concentrations in three communities located in northern Mexico: Ciudad Juarez, Samalayuca, and Villa Ahumada. In these communities the fluoride concentration in water averages 0.3, 1.0, and 5.3 mg/L, respectively. The residents of
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The effects of high levels of fluoride and iodine on intellectual ability and the metabolism of fluoride and iodine.
The authors carried out a study on the intellectual abilities and fluoride/iodine metabolism of children living in a high fluoride-high iodine area. Among the results: the percentage of the general population living in this fluoride/iodine-contaminated region that suffered from goiter (clinical thyroid enlargement) was 3.8%, the rate of children already showing some thyroid
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Fluoride's Impact on Thyroid Hormones
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Fluoride Aggravates Thyroid Damage Caused by Excess Iodine Intake
Chinese researchers have found that the combination of excess fluoride with excess iodine caused greater reductions in IQ, or greater increases in goitre than either scenario by itself.
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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NRC (2006): Fluoride's Impact on the Thyroid Gland
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