Abstract
Effects of morphine and aluminum fluoride on field potentials evoked in hippocampal pyramidal cells were investigated revealing the physiological significance of adenylate cyclase in morphine action. Dibutyryl-cyclic AMP (db-cAMP) reduces the amplitude of potentials, while morphine enhances it. Morphine was without effects on db-cAMP induced reduction of potentials. Aluminum fluoride, known to activate GTP binding proteins, also reduced potentials and this was antagonized by morphine. Furthermore, N-[2-(methylamino)ethyl]-5-isoquinolinesulphonamide dihydrochloride (H-8), a protein kinase A inhibitor, enhanced potentials. When GABA synthesis was inhibited by 3-mercaptopropinoic acid, both morphine and db-cAMP was without effect. These results suggested the inhibition of adenylate cyclase by morphine which might be related with the reduction of GABA release in hippocampal slices.
-
-
Effect of high-fluoride water supply on children’s intelligence.
In Shanxi Province, China, children living in the endemic fluoride village of Sima (water supply F = 4.12 mg/L) located near Xiaoyi City had average IQ (97.69) significantly lower (p < 0.02) than children living to the north in the nonendemic village of Xinghua (F = 0.91 mg/L; average IQ = 105.21). These differences were not
-
Proteome alterations in cortex of mice exposed to fluoride and lead
Both fluoride and lead can cross the blood-brain barrier and produce toxic effects on the central neural system, resulting in low learning and memory abilities, especially in children. In order to identify the proteomic pattern in the cortex of young animals, from the beginning of fertilization to the age of
-
Effect of fluoride on the proteomic profile of the hippocampus in rats
Two-dimensional gel electrophoresis (2-DE) was used to detect fluoride-induced alterations in the proteome of the rat hippocampus. Male Sprague-Dawley rats (n=30) were subjected to treatments three weeks after weaning. Animals of the first group were injected intraperitoneally (i.p.) with aqueous NaF (20 mg/kg/body weight/day), the second group, injected with physiological
-
Amelioration by jambul fruit extract of fluoride-induced hepato-nephronal histopathologies and impaired neuromotor capacity in mice.
We studied the amelioration potential of jambul (Syzygium cumini) fruit extract (JE) on fluoride ion (F) mediated behavioral alterations and hepato-nephronal histopathologies in four groups (n=10 per group) of adult male mice. Two groups, control (C) and jambul (J), were fed F-free water for 15 days while the other two
-
Intelligence and fluoride exposure in New Zealand children
A birth cohort of 1265 children born in Christchurch in 1977 was studied longitudinally including assessment measures of cognitive ability at ages 8 and 9 years using the Wechsler Intelligence Scale for Children (WISC-R). It was possible to study the association between intelligence and fluoride exposure as approximately half of
Related Studies :
-
-
-
Fluoride's Direct Effects on Brain: Animal Studies
The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.
-
NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects
The NRC's analysis on fluoride and the brain.
-
Fluoride & IQ: 68 Studies
As of February 2021, a total of 76 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 68 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or
-
Fluoride Affects Learning & Memory in Animals
An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out
-
Fluoride: Developmental Neurotoxicity.
Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching
Related FAN Content :
-