In this study, the effects of sodium fluoride given subchronically at the doses of 1, 10 and 40 mg/L for 70 days were investigated. For this purpose, 21 male New Zealand rabbits were used. At the end of the 70th day, the level of blood urea nitrogen (BUN), creatine (CRE) and y-GT activity in the plasma and the activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Rd), catalase (CAT) and glucose 6-phosphate dehydrogenase (G6PD) and the level of malondialdehyde (MDA) were detected from blood samples taken from the control group (1 mg/L) and the trial group (10 mg/L and 40 mg/L). There was a significant increase in the level of BUN, CRE and y-GT and MDA activity, which was correlated with the increase in dose. When compared with the control group, a significant increase in the trial group given 10 ppm fluoride and a significant decrease in the group given 40 ppm fluoride were detected in the activity of SOD, GSH-Px, GSH-Rd and CAT. Only in the group given 40 ppm flouride was a significant decrease detected. In addition, the fluoride level significantly increased.
A significant increase was seen in the levels of plasma BUN and CRE and the activity of tissue MDA with the increase in fluoride in the drinking water. The activity level of the antioxidant enzymes SOD, GSH-Px, GSH-Rd, CAT and G6PD varied according to the dose. A significant increase in the 10 ppm group and a significant decrease in the 40 ppm in these enzymes activities.