Forty-five male patients suffering from chronic fluorine poisoning and fifteen normal men were investigated. The urinary excretion of oestrone, oestradiol-17?, oestriol and 16-epioestriol was studied. The results revealed a high content of oestrogens in urine. This is explained by a metabolic disorder in the liver.
Changes of DNA repair gene methylation in blood of chronic fluorosis patients and rats.
To investigate the relationship between DNA repair gene methylation and chronic coal-burning fluorosis. The methylation rates of O6-methylguanine-DNA- methyltransferase gene MGMT, a DNA repair gene and mismatch repair gene MutL homolog 1 (MLH1) were analysed by methylation of specific PCR (MSP), and the levels of mRNA in the blood of
Evaluation of multi-endpoint assay to detect genotoxicity and oxidative stress in mice exposed to sodium fluoride
Fluoride compounds are naturally present in soil, water and food. The objective of this study was to investigate the genotoxic and oxidative damage induced by chronic fluoride exposure on mammalian cells in vivo. For this purpose, the genotoxic potential was investigated in bone marrow cells by the micronucleus test, chromosome
Investigations of soft tissue functions in fluorotic individuals of North Gujurat
The present study was undertaken to investigate the various health problems caused by water-borne fluoride in endemic villages of Mehsana and Banaskantha districts of Gujarat. The study revealed high levels of fluoride in serum samples of the villagers. Mottling of teeth and skeletal complications were common. Intake of fluoride caused
Fluoride exposure and kidney and liver function among adolescents in theUnited States: NHANES, 2013–2016.
Highlights Plasma fluoride concentrations are associated with kidney and liver parameters among United States (U.S.) adolescents Higher water fluoride concentrations are associated with lower blood urea nitrogen among U.S. adolescents Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents Altered kidney and/or liver
Liver damage in chronic fluoride intoxication
Cases of chronic fluoride intoxication due to industrial hazards are rarely reported in the medical literature. The following brief case report of chronic fluoride poisoning is of special interest because of liver involvement, a rarely described feature of the disease. It was presented to the editor in a letter by
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