Abstract

Forty-five male patients suffering from chronic fluorine poisoning and fifteen normal men were investigated. The urinary excretion of oestrone, oestradiol-17?, oestriol and 16-epioestriol was studied. The results revealed a high content of oestrogens in urine. This is explained by a metabolic disorder in the liver.

• Related Studies :

  • Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice.

    Arsenic and fluoride are potent toxicants, widely distributed through drinking water and food and often result in adverse health effects. The present study examined the effects of sodium meta-arsenite (100 mg/l in drinking water) and sodium fluoride (5 mg/kg, oral, once daily), administered either alone or in combination for 8

  • Histological and histochemical appearance of livers and kidneys of rats after long-term treatment with different concentrations of sodium fluoride in drinking water

    After a review of the controversies in the literature, a histologic and histochemical study of the livers and kidneys of 48 albino rats was performed. The animals were placed on a diet containing 1 ppm NaF in demineralized drinking water, or 1, 10 or 100 ppm NaF in tap water

  • Absence of DNA damage in multiple organs (blood, liver, kidney, thyroid gland and urinary bladder) after acute fluoride exposure in rats

    Fluoride has been widely used in dentistry as a caries prophylactic agent. However, there has been some speculation that excess fluoride could cause an impact on genome integrity. In the current study, the potential DNA damage associated with exposure to fluoride was assessed in cells of blood, liver, kidney, thyroid

  • Effect of long term fluoride exposure on lipid composition in rat liver

    Chronic fluorosis can severely damage many systems of human body, but its pathogenesis is unclear. Normal composition and structure of cellular membrane lipids are a basic factor to maintain cell function. In this investigation, cellular membrane lipids of the liver were analysed after a long term fluoride treatment for rats

  • Liver damage in chronic fluoride intoxication

    Cases of chronic fluoride intoxication due to industrial hazards are rarely reported in the medical literature. The following brief case report of chronic fluoride poisoning is of special interest because of liver involvement, a rarely described feature of the disease. It was presented to the editor in a letter by