Abstract

The influence of fluorine administration on central nervous system’s (CNS) performances in female mice treated during gestation with two distinct doses of sodium fluoride (NaF): 0.25 mg and 0.50 mg. The research extended also to offspring (generation 1 – F1), treated with NaF in allopathic (0.25 and 0.50 mg), homeopathic (7CH) or with the association between the two types (allopathic and homeopathic) of doses. CNS performance modification was also assessed in the second generation offspring (F2), in which fluorine was exclusively taken from ascendant generations. Evaluation of CNS activity was performed by determining clearing time in classic maze (CM) at several time intervals (roughly 21 days between determinations). Experimental results showed that, in young offspring (1 – F1) from ascendants treated with the same substance, CNS performances in investigative capacity are influenced depending on dose, gender and age. Similar effect was recorded for homeopathic remedy 7CH for which the influence on CNS performance is strongly correlated to the stage of physical development of offspring and to doses of NaF administered to ascendants. The results of pharmacological tests correlate strongly to modifications noted during anatomical pathology examination of cerebral cortex.

• Related Studies :

  • [Effects of selenium on the damage of learning-memory ability of mice induced by fluoride].

    Sodium fluoride added with or without selenite in deionized water was administered to male mice for 8 weeks. The influences of fluoride on learning-memory behavior were tested on Y-maze, and the ultrastructure of Gray 1 synaptic interface in the CA3 area hippocampus was qualitatively analyzed by electron microscopy and computer

  • Effects of chronic fluoride exposure on object recognition memory and mRNA expression of SNARE complex in hippocampus of male mice

    This study aimed to investigate the effects of long-term fluoride exposure on object recognition memory and mRNA expression of soluble N-ethylmaleimidesensitive fusion protein attachment protein receptors (SNARE) complex (synaptosome-associated protein of 25 kDa (SNAP-25), vesicle-associated membrane protein 2 (VAMP-2), and syntaxin 1A) in the hippocampus of male mice. Sixty sexually matured

  • Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content

    Objective: Explore the brain mechanism of the effect of fluorosis on learning and memory behavior. Method: A method combining behavioral observation and biochemical testing was used to study the effects of long-term drinking different concentrations of sodium fluoride on mouse learning and memory behavior and changes in content of brain

  • The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats

    Objective: Explore the effect and possible mechanisms of fluorine exposure of pregnant rats passing through placental barriers on the learning and memory capabilities of baby rats. Method: Open field behavior and a water maze test were used to observe the effects on the spontaneous behavior and learning and memory on baby

  • Psychopharmacology of fluoride: a review

    Although the blood-brain barrier is relatively impermeable to fluoride, it does not pose an absolute barrier and fluoride has the ability to enter the brain. The literature was examined to assess the quality of the evidence for cerebral impairment occurring due to exposure to fluoride from therapeutic or environmental sources.

• Related FAN Content :

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.