Abstract
Two studies were conducted to investigate the placental transfer of fluoride in the guinea pig. Adult female guinea pigs were provided various levels of fluoride ranging from 1 to 50 ppm during gestation and the amount of fluoride retained in the foetus at birth was determined. The results obtained indicate that a significant placental transfer of fluoride occurs in the guinea pig at all levels of fluoride provided during gestation.
The results also indicate that the previous exposure of the mothers to fluoride prior to gestation influences the amount of fluoride transferred to the foetal tissues with the second generation of offspring retaining more fluoride during foetal development than the first generation.
Collectively, these data suggest that the guinea pig may be an acceptable means of evaluating the placental transfer of fluoride in the human although one must exercise considerable caution in translating these findings to the human due to the large amount of species variation which has been shown in previous studies.
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Evaluation of a fluorosis prevention educational program: A randomized field trial.
Background: A 2-group randomized field trial was conducted to evaluate the impact of a fluorosis educational preventive program in mother´s knowledge and practices, and on the urine fluoride concentration of their preschool children. Material and Methods: A group of 139 mother-child pairs participated in the study. Randomly, children were assigned to an intervention
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Fluoride exposure from groundwater as reflected by urinary fluoride and children's dental fluorosis in the Main Ethiopian Rift Valley.
This cross-sectional study explores the relationships between children's F(-) exposure from drinking groundwater and urinary F(-) concentrations, combined with dental fluorosis (DF) in the Main Ethiopian Rift (MER) Valley. We examined the DF prevalence and severity among 491 children (10 to 15 years old) who are life-long residents of 33
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Relationship between bone mineral loss and urinary fluoride concentration in postmenopausal Japanese women
The purpose of this study was to evaluate the relationship between bone mineral loss and urinary fluoride (F) concentration in postmenopausal Japanese women. Lumbar spinal bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) at baseline and 1 year later in 94 premenopausal and 100 postmenopausal women. None
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Fluoride ingestion and thyroid function in children resident of naturally fluoridated areas - An observational study.
Background: Literature shows association between systemic fluorides with water fluoride level above 3ppm and endocrine disorders especially related to thyroid. Aim & Objectives: To estimate serum T3, T4, TSH, Fluoride levels among children with normal nutritional status and optimal iodine intake, residing in three different ranges of drinking water fluoride levels
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Concentrations of ionic, total, and bound fluoride in plasma
We found no significant difference between the means for ionic, bound, and total fluoride concentrations in the plasma of male and female subjects of the same age, living in a community with fluoridated water. When results for the 264 fasting subjects were therefore combined according to age, they indicated that
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,
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Annapolis: Water Fluoridation Linked to Death of Dialysis Patient
EVENING CAPITAL (Annapolis, Maryland) November 29, 1979 Fluoride Linked to Death by Mary Ann Kryzankowicz Staff Writer Fluoride poisoning has been definitely linked to the death of a 65-year-old kidney dialysis patient who became ill during a blood cleaning process Nov 11. State Medical Examiner Dr. (illegible) Guard has ruled that Lawrence Blake, 65, of Arundel
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Skeletal Fluorosis & Individual Variability
One of the common fallacies in the research on skeletal fluorosis is the notion that there is a uniform level of fluoride that is safe for everyone in the population. These "safety thresholds" have been expressed in terms of (a) bone fluoride content, (b) daily dose, (c) water fluoride level, (d) urinary fluoride level, and (e) blood fluoride level. The central fallacy with each of these alleged safety thresholds, however, is that they ignore the wide range of individual susceptibility in how people respond to toxic substances, including fluoride.
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