Fluoride Action Network

Abstract

Inorganic arsenic (iAs) and fluoride (F?) are naturally occurring drinking water contaminants. However, co-exposure to these contaminants and its effects on human health are understudied. The goal of this study was examined exposures to iAs and F? in Chihuahua, Mexico, where exposure to iAs in drinking water has been associated with adverse health effects. All 1119 eligible Chihuahua residents (>18 years) provided a sample of drinking water and spot urine samples. iAs and F? concentrations in water samples ranged from 0.1 to 419.8 µg As/L and from 0.05 to 11.8 mg F?/L. Urinary arsenic (U-tAs) and urinary F? (U-F?) levels ranged from 0.5 to 467.9 ng As/mL and from 0.1 to 14.4 µg F?/mL. A strong positive correlation was found between iAs and F? concentrations in drinking water (rs = 0.741). Similarly, U-tAs levels correlated positively with U-F? concentrations (rs = 0.633). These results show that Chihuahua residents exposed to high iAs concentrations in drinking water are also exposed to high levels of F?, raising questions about possible contribution of F? exposure to the adverse effects that have so far been attributed only to iAs exposure. Thus, investigation of possible interactions between iAs and F? exposures and its related health risks deserves immediate attention. View Full-Text

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*Original abstract online at https://www.mdpi.com/1660-4601/12/5/4587