Abstract

Excerpt:

• Introduction
• Case Presentation
• Discussion

Conclusions

Adult variants of osteopetrosis and fluorosis have similar symptoms and radiological findings including an increased bone mineral density. However, the underlying pathophysiology of increased bone density distinguishes osteopetrosis from fluorosis. Osteopetrosis is characterized by decreased bone resorption in contrast to fluorosis which is characterized by increased bone formation. Fluorosis can result in reversible musculocutaneous symptoms and radiological findings and disease progression correlates with the length of exposure to fluoride. However, severe chronic cases may develop irreversible neurologic involvement. Urinary fluoride testing is the most accurate screening modality, and the key component of management is the removal of the source of fluoride intoxication as well as monitoring of urinary fluoride levels.

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References

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